Document Detail


Voxel based morphometry reveals specific gray matter changes in primary dystonia.
MedLine Citation:
PMID:  17588241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel-based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender-matched controls were included. When compared with healthy controls, patients with primary dystonia (n=31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes.
Authors:
Karl Egger; Joerg Mueller; Michael Schocke; Christian Brenneis; Martina Rinnerthaler; Klaus Seppi; Thomas Trieb; Gregor K Wenning; Mark Hallett; Werner Poewe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  22     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1538-42     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 Movement Disorder Society.
Affiliation:
Department of Radiology, Innsbruck Medical University, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Brain / pathology*
Brain Mapping
Dystonic Disorders / classification,  pathology*
Female
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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