Document Detail

Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET.
MedLine Citation:
PMID:  23281426     Owner:  NLM     Status:  MEDLINE    
In vivo imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an (18)F-labeled TSPO ligand, [(18)F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume.
Ji Hyun Ko; Yuko Koshimori; Romina Mizrahi; Pablo Rusjan; Alan A Wilson; Anthony E Lang; Sylvain Houle; Antonio P Strafella
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-02
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-01     Completed Date:  2013-04-19     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-50     Citation Subset:  IM    
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MeSH Terms
Anilides / administration & dosage*
Biological Markers / metabolism
Brain Neoplasms / metabolism,  radiography
Meningioma / metabolism,  radiography
Microglia / metabolism*,  pathology
Middle Aged
Neoplasm Proteins / metabolism
Nerve Tissue Proteins / metabolism*
Positron-Emission Tomography / methods*
Pyridines / administration & dosage*
Receptors, GABA / metabolism*
Grant Support
117891-1//Canadian Institutes of Health Research; MOP 110962//Canadian Institutes of Health Research
Reg. No./Substance:
0/Anilides; 0/Biological Markers; 0/N-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluoride; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Pyridines; 0/Receptors, GABA; 0/TSPO protein, human

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