Document Detail

Voxel-based analysis of Tc-99m ECD brain perfusion SPECT in patients with normal pressure hydrocephalus.
MedLine Citation:
PMID:  19318265     Owner:  NLM     Status:  MEDLINE    
Idiopathic normal pressure hydrocephalus (iNPH) is a reversible dementia characterized by gait disturbance, incontinence and dementia. This study investigates the neuropsychological characteristics and changes of regional cerebral blood flow (rCBF) in patients with iNPH. Ten patients who met the criteria of probable iNPH and 13 normal control subjects were evaluated. The general cognitive function and detailed neuropsychological functions were measured by K-MMSE and comprehensive neuropsychological battery. Tc-99m-ethyl cysteinate dimmer (Tc-99m-ECD) single photon emission computed tomography (SPECT) was performed to measure the rCBF and statistical parametric mapping (SPM) and statistical probabilistic brain anatomic map (SPAM) was applied to the objective analysis of SPECT data. On the neuropsychological examination, all the patients showed abnormality in memory, psychomotor speed and frontal executive function. SPM analysis of SPECT images revealed that rCBF in bilateral thalami, right prefrontal area, bilateral anterior and posterior cingulate gyri, right caudate nucleus, and left parahippocampal gyrus was significantly decreased in patients with iNPH compared to normal controls (uncorrected P<0.005). In SPAM analysis, rCBF reduction was observed in bilateral prefrontal area, anterior, posterior cingulate gyri and caudate nuclei. We have found that rCBF changes occurred predominantly in prefrontal and subcortical areas, the changes were associated with frontal subcortical circuit, and the affected frontal subcortical circuit may contribute to the cognitive decline seen in the iNPH patients. The reduction of rCBF and clinical cognitive impairment are closely connected in patients with iNPH.
Bora Yoon; Dong-Won Yang; Yong-Soo Shim; Sung-Woo Chung; Kook-Jin Ahn; Joo-Hyun O; Sung-Hoon Kim; Hyung-Sun Sohn; Soo-Kyo Chung; Yong-An Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-25
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  67     ISSN:  1872-9800     ISO Abbreviation:  Appl Radiat Isot     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  1377-81     Citation Subset:  IM    
Department of Neurology, The College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
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MeSH Terms
Brain Mapping / methods
Case-Control Studies
Cerebrovascular Circulation
Cognition Disorders / etiology
Cysteine / analogs & derivatives,  diagnostic use
Hydrocephalus, Normal Pressure / physiopathology,  radionuclide imaging*
Middle Aged
Neuropsychological Tests
Organotechnetium Compounds / diagnostic use
Tomography, Emission-Computed, Single-Photon / methods*
Reg. No./Substance:
0/Organotechnetium Compounds; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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