| A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas. | |
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MedLine Citation:
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PMID: 21770759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The Objective is to study the correlations and the differences in glucose metabolism between the thalamus and cortical structures in a sample of severe traumatic brain injury (TBI) patients with different neurological outcomes. We studied 49 patients who had suffered a severe TBI and 10 healthy control subjects using 18F-FDG-PET. The patients were divided into three groups: the MCS&VS group (n=17), which included patients who were in a vegetative or a minimally conscious state; the In-PTA group (n=12), which included patients in post-traumatic amnesia (PTA); and the Out-PTA group (n=20), which included patients who had recovered from PTA. SPM5 software was used to determine the metabolic differences between the groups. FDG-PET images were normalized and four regions of interest were generated around the thalamus, precuneus and the frontal and temporal lobes. The groups were parameterized using the Student's T-test. Principal component analysis was used to obtain an intensity-estimated-value per subject to correlate the function between the structures. Differences in glucose metabolism in all structures were related to the neurological outcome, and the most severe patients showed the most severe hypometabolism. We also found a significant correlation between the cortico-thalamo-cortical metabolism in all groups. Voxel-based analysis suggests a functional correlation between these four areas and decreased metabolism was associated with less favorable outcome. Higher levels of activation of the cortico-cortical connections appear to be related to better neurological conditions. Differences in the thalamo-cortical correlations between patients and controls may be related to traumatic dysfunction due to focal or diffuse lesions. |
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Authors:
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Javier García-Panach; Nuria Lull; Juan José Lull; Joan Ferri; Carlos Martínez; Pablo Sopena; Montserrat Robles; Javier Chirivella; Enrique Noé |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: Journal of neurotrauma Volume: - ISSN: 1557-9042 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Servicio de Daño Cerebral de los Hospitales NISA. Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Neuroimaging, Valencia, Spain; panaka7@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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