| Voxel-based analysis of asymmetry index maps increases the specificity of 18F-MPPF PET abnormalities for localizing the epileptogenic zone in temporal lobe epilepsies. | |
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MedLine Citation:
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PMID: 21051649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: (18)F-MPPF PET scans of 24 TLE patients who achieved an Engel class I outcome after epilepsy surgery and of 41 controls were analyzed visually, with standard SPM, and by computing voxel-based AIs. Both SPM methods were assessed using 2 different statistical thresholds (P < 0.05, corrected at the cluster level, and P < 0.05, familywise error (FWE) corrected at the voxel level). Sensitivity and specificity of each method were estimated and compared using McNemar tests. RESULTS: The sensitivity of AI analysis to detect decreases of (18)F-MPPF binding potential ipsilateral to the epileptogenic lobe was 92% (P < 0.05, corrected at the cluster level) and 96% (P < 0.05, familywise error corrected at the voxel level), whereas specificity (defined as the congruence between the localization of the voxel associated with the greatest z score and that of the epileptogenic zone) was 88% at both thresholds. AI analysis was significantly more sensitive (P < 0.05) and specific (P < 0.005) than standard SPM analysis, regardless of the applied threshold. AI analysis also proved to be more sensitive than visual analysis. CONCLUSION: AI analysis of (18)F-MPPF PET was more sensitive and specific than previous methods of analysis. This noninvasive imaging procedure was especially informative for the presurgical assessment of patients presenting with clinical histories atypical of mesial TLE or with normal brain MRI results. |
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Authors:
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Adrien Didelot; François Mauguière; Jérôme Redouté; Sandrine Bouvard; Amélie Lothe; Anthonin Reilhac; Alexander Hammers; Nicolas Costes; Philippe Ryvlin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1732-9 Citation Subset: IM |
Affiliation:
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INSERM, U879, Hôpital Pierre Wertheimer, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Drug Resistance Epilepsy, Temporal Lobe / drug therapy, radionuclide imaging* Female Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Piperazines / diagnostic use* Positron-Emission Tomography / methods* Prognosis Pyridines / diagnostic use* Reproducibility of Results Sensitivity and Specificity Young Adult |
| Chemical | |
Reg. No./Substance:
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0/4-(2'-methoxyphenyl)-1-(2'-(N-2'-pyridinyl)-p-(18F)fluorobenzamido )ethylpiperazine; 0/Piperazines; 0/Pyridines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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