Document Detail

Voriconazole versus natamycin as primary treatment in fungal corneal ulcers.
MedLine Citation:
PMID:  21105974     Owner:  NLM     Status:  In-Data-Review    
Background:  To evaluate the efficacy of topical 1% voriconazole versus 5% natamycin in treatment of fungal corneal ulcers. Design:  A prospective, randomized pilot study in a tertiary care hospital. Participants:  Thirty patients of microbiologically proven fungal keratitis divided randomly in two groups of 15 patients each. Methods:  Two groups were treated with either 5% natamycin (group A) or 1% voriconazole (group B) topically as a primary treatment for fungal keratitis. The mean size, depth of infiltrate and LogMAR visual acuity at presentation were comparable in both groups (P > 0.05). Patients were followed up for minimum of 10 weeks or till complete resolution of ulcer, whichever was later. Cultures to identify the causative organisms were performed. Main Outcome Measure:  Time of resolution of the ulcer. Results:  Twenty-nine of the total 30 patients showed complete resolution. Average time of resolution and gain in LogMAR visual acuity was 24.3 days and 1.12 in group A and 27.2 days and 0.77 in group B. These were comparable in the two groups (P > 0.05%). Aspergillus spp. (40%) and Curvularia spp. (30.0%) were found to be most common isolates. Conclusion:  Topical 1% voriconazole was found to be safe and effective drug in primary management of fungal keratitis, its efficacy matching conventional natamycin. There was no added advantage of using topical 1% voriconazole over topical natamycin as primary treatment in fungal keratitis.
Ritu Arora; Deepa Gupta; Jawaharlal Goyal; Ravinder Kaur
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Publication Detail:
Type:  Journal Article     Date:  2011-06-28
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  39     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  434-40     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists.
Guru Nanak Eye Centre Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
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