Document Detail


Voriconazole for the treatment of disseminated nodular cutaneous aspergillosis in a patient affected by acute myeloid leukemia.
MedLine Citation:
PMID:  15048069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a 44-year-old patient with refractory acute myeloid leukemia who developed a rare form of disseminated cutaneous aspergillosis resulting from colonization in the deep reticular dermis of Aspergillus flavus. Diagnosis was based on cutaneous biopsy. Antifungal therapy was started with liposomal amphotericin B (L AmB). However, the lesions continued to spread and there was a marked decline in the patient's clinical condition. Consequently, L AmB was replaced with voriconazole. Response to voriconazole was excellent with regression of the skin lesions and a rapid improvement of the patient's general clinical condition.
Authors:
Giorgio La Nasa; Roberto Littera; Antonello Maccioni; Antonio Ledda; Adriana Vacca; Licinio Contu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The hematology journal : the official journal of the European Haematology Association / EHA     Volume:  5     ISSN:  1466-4860     ISO Abbreviation:  Hematol. J.     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100965523     Medline TA:  Hematol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  IM    
Affiliation:
Centro Trapianti di Midollo Osseo, Centro Regionale Trapianti, Ospedale R. Binaghi, ASL n. 8, Cagliari, Sardinia, Italy. lanasa@tiscalinet.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Amphotericin B / therapeutic use
Antifungal Agents / therapeutic use*
Aspergillosis / drug therapy*,  etiology,  microbiology,  pathology
Aspergillus flavus*
Dermatomycoses / drug therapy*,  microbiology,  pathology
Female
Humans
Leukemia, Myeloid, Acute* / complications
Pyrimidines / therapeutic use*
Triazoles / therapeutic use*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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