Document Detail


Voriconazole in the treatment of fungal eye infections: a review of current literature.
MedLine Citation:
PMID:  18577634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Voriconazole has an important role to play in the prophylaxis and management of fungal endophthalmitis and keratitis. New-generation triazoles, including voriconazole, posaconazole and ravuconazole, have been shown in laboratory studies and clinical experience to have very good safety profiles with few side effects. Fungal eye infections, while not common in temperate climates, have been notoriously difficult to diagnose and treat, and generally result in protracted therapy with poor final outcomes. Current treatment options are far from optimal. AIMS: This paper will review studies and clinical case reports published in the ophthalmic literature that address the safety of these drugs in the eye, penetration and concentration in ocular tissues and media, and efficacy in treating common pathogens implicated in fungal keratitis and endophthalmitis. CONCLUSIONS: Over 40 clinical case reports of treatment with voriconazole suggest that it may be used safely and effectively against a broad range of fungal pathogens.
Authors:
S M Hariprasad; W F Mieler; T K Lin; W E Sponsel; J R Graybill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  92     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  871-8     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Science, Vitreoretinal Service, University of Chicago, 5841 South Maryland Avenue-MC 2114, Chicago, IL 60637, USA. retina@uchicago.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / adverse effects,  pharmacokinetics,  therapeutic use*
Eye Infections, Fungal / drug therapy*,  metabolism
Humans
Pyrimidines / adverse effects,  pharmacokinetics,  therapeutic use*
Treatment Outcome
Triazoles / adverse effects,  pharmacokinetics,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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