Document Detail

Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis.
MedLine Citation:
PMID:  19284017     Owner:  NLM     Status:  MEDLINE    
Allergic bronchopulmonary aspergillosis (ABPA) can cause a significant clinical deterioration in patients with cystic fibrosis. There is very little research in the current literature with regard to alternatives for treatment, apart from long courses of steroids. We conducted a retrospective review of all our patients with ABPA treated with the antifungal voriconazole and found there was a significant drop in IgE levels post treatment as well as a decrease in steroid dosing. The improvement in FEV was not statistically significant; however there was a very wide variation in pre-treatment levels.
L Glackin; G Leen; B Elnazir; P Greally
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish medical journal     Volume:  102     ISSN:  0332-3102     ISO Abbreviation:  Ir Med J     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-04-28     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0430275     Medline TA:  Ir Med J     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  29     Citation Subset:  IM    
Department of Respiratory Medicine, National Children's Hospital, Tallaght, Dublin 24.
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MeSH Terms
Antifungal Agents / therapeutic use*
Aspergillosis, Allergic Bronchopulmonary / drug therapy*,  etiology
Confidence Intervals
Cystic Fibrosis / complications*,  physiopathology
Forced Expiratory Volume
Immunoglobulin E / blood,  drug effects
Pyrimidines / therapeutic use*
Retrospective Studies
Triazoles / therapeutic use*
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 37341-29-0/Immunoglobulin E

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