Document Detail


Von Willebrand factor and autoantibodies against oxidized LDL in hemodialysis patients treated with vitamin E-modified dialyzers.
MedLine Citation:
PMID:  15112887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidant stress is a well known cause of damage in the atherosclerotic process. Vitamin E is one of the most promising natural antioxidants. In this study we investigated if a vitamin E-coated dialyzer was able to reduce the plasma levels of auto-antibodies against oxidized-LDL, von Willebrand factor (vWf) and thrombomodulin (TM) as markers of endothelial damage. In this controlled 6-month prospective study, we investigated these markers in two matched groups (n=16 each) of patients on regular hemodialysis not yet diagnosed for atherosclerosis cardiovascular disease (ACVD) (mean age=58.3+/-7.0 yrs, mean dialysis age=30.1+/-10.0 months), in which cellulosic (CLS) and vitamin E-modified dialyzers (CLE) were compared. At inclusion all the patients were treated with CLS. Then, the study group was shifted to CLE for 6 months. At baseline the patients showed normal levels of vitamin E and high levels of oxLDL-Ab, vWf and TM compared to healthy subjects. In the CLE group oxLDL-Ab and vWf, but not TM levels, decreased progressively (from 472+/-287 to 264+/-199 mU/mL, p<0.0001 and from 101.1+/-7.5% to 76.7+/-18.5%; p<0.001, respectively), and vitamin E increased from 4.40+/-0.81 to 7.81+/-1.16 microg/mg of cholesterol. At the end of the study, 8 of the patients treated with CLE were randomly selected and went back to the membrane without Vitamin E for six months. They showed an significant increase in OxLDL-Ab and vWf levels and a significant reduction in tocoferol levels. In conclusion, CLE compared to cellulosic dialyzers can lower some indices of damage to LDL and endothelial cells.
Authors:
G Bufano; M Usberti; S Mandolfo; F Malberti; M Piroddi; F Galli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  27     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-28     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Dialysis, Cremona Hospital, Italy. giuseppe_bufano@yahoo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / pharmacology*
Autoantibodies / biosynthesis*
Cholesterol, LDL / immunology
Controlled Clinical Trials as Topic
Cross-Sectional Studies
Endothelial Cells / drug effects
Humans
Kidney Failure, Chronic / therapy
Membranes, Artificial*
Middle Aged
Oxidative Stress / physiology
Prospective Studies
Renal Dialysis / instrumentation*
Thrombomodulin / immunology
Vitamin E / pharmacology*
von Willebrand Factor / biosynthesis*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Autoantibodies; 0/Cholesterol, LDL; 0/Membranes, Artificial; 0/Thrombomodulin; 0/von Willebrand Factor; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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