Document Detail

Von Willebrand factor as marker of vascular function in South African women: the POWIRS Study.
MedLine Citation:
PMID:  18820655     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The increasing prevalence of hypertension and vascular-related morbidity and mortality among Africans emphasizes the need to identify markers for the early detection of vascular disease. Caucasian-based studies demonstrate that the von Willebrand factor (vWf) is a useful marker of vascular dysfunction. We investigated whether associations between this marker and markers of cardiovascular function in Caucasian women are comparable with African women.
METHODS: The study consisted of apparently healthy African (n = 99) and Caucasian (n = 114) women (mean age, 31.0 years), individually matched for age and body mass index. We measured blood pressure and arterial compliance noninvasively, and vWf in serum. We assessed univariate and multivariate-adjusted associations of blood pressure and arterial compliance with vWf.
RESULTS: Although no ethnic difference existed for mean vWf levels, Caucasian and African women showed opposite associations of blood pressure and arterial compliance with vWf after single, partial, and multiple regression analyses. In Caucasians, after full adjustment, systolic (beta = +0.179; P < 0.05) and diastolic (beta = +0.190; P < 0.05) blood pressure correlated positively and arterial compliance negatively (beta = -0.197; P < 0.01) with vWf. Conversely, in Africans, systolic blood pressure correlated weakly, but negatively (beta = -0.168; P = 0.059) with vWf. However, this opposite tendency seemed due to the confounding influence of the depot medroxyprogesterone acetate (DMPA) contraceptive injection and, although >99% power existed, significance disappeared after excluding these subjects (beta = -0.071; P = 0.46).
CONCLUSIONS: Associations of vWf with blood pressure and arterial compliance were not comparable between Caucasian and African women, suggesting that the vWf may not be a useful marker of vascular alterations in African women.
Rudolph Schutte; Aletta E Schutte; Johannes M Van Rooyen; Hugo W Huisman; Iolanthé M Palmer; Carla M Fourie; Szabolcs Péter; Leoné Malan; Nicolaas T Malan; Manja Reimann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-25
Journal Detail:
Title:  American journal of hypertension     Volume:  21     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-09     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1298-303     Citation Subset:  IM    
Subject Group Physiology, School for Physiology, Nutrition, and Consumer Sciences, North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
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MeSH Terms
African Continental Ancestry Group / statistics & numerical data*
Analysis of Variance
Biological Markers / blood
Blood Pressure Determination / methods
European Continental Ancestry Group / statistics & numerical data*
Hypertension / blood*,  ethnology*
Middle Aged
Multivariate Analysis
Sampling Studies
South Africa / ethnology
Vascular Resistance
von Willebrand Factor / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/von Willebrand Factor
Comment In:
Am J Hypertens. 2008 Dec;21(12):1275-6   [PMID:  19020507 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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