Document Detail


Von Willebrand factor and the right ventricle (the MESA-Right Ventricle Study).
MedLine Citation:
PMID:  22995970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevation in plasma activity of von Willebrand factor (vWF) reflects endothelial dysfunction and predicts death in pulmonary arterial hypertension. Higher vWF activity is also associated with a lower right ventricular (RV) ejection fraction in pulmonary arterial hypertension. Little is known about the relation between vWF and RV structure and function in adults without cardiovascular disease. The present investigation included 1,976 participants with magnetic resonance imaging assessment of RV structure and function and measurement of vWF activity from the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to estimate the associations between vWF activity and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking, diabetes mellitus, hypertension, and the corresponding left ventricular parameter. The average vWF activity was 140.7 ± 57.2%. Elevated vWF activity was independently associated with lower RV mass, RV end-diastolic volume, and RV stroke volume in models with and without adjustment for the corresponding left ventricular parameter (all p values <0.05). There was no association observed between vWF activity and the RV ejection fraction. In conclusion, higher vWF activity is associated with lower RV mass, RV end-diastolic volume, and RV stroke volume. These associations are independent of common cardiovascular risk factors and left ventricular morphologic changes.
Authors:
Peter J Leary; R Graham Barr; David A Bluemke; Michael R Bristow; Catherine L Hough; Richard A Kronmal; Joao A Lima; Robyn L McClelland; Russell P Tracy; Steven M Kawut
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2012-09-18
Journal Detail:
Title:  The American journal of cardiology     Volume:  110     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-04-16     Revised Date:  2014-06-27    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1846-51     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cardiac Volume
Cardiovascular Diseases / ethnology
Female
Heart Ventricles / anatomy & histology,  physiopathology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prospective Studies
Ventricular Function, Right / physiology*
von Willebrand Factor / analysis*
Grant Support
ID/Acronym/Agency:
K24 HL103844/HL/NHLBI NIH HHS; K24-HL103844/HL/NHLBI NIH HHS; N01-HC95159/HC/NHLBI NIH HHS; N01-HC95160/HC/NHLBI NIH HHS; N01-HC95161/HC/NHLBI NIH HHS; N01-HC95162/HC/NHLBI NIH HHS; N01-HC95163/HC/NHLBI NIH HHS; N01-HC95164/HC/NHLBI NIH HHS; N01-HC95165/HC/NHLBI NIH HHS; N01-HC95169/HC/NHLBI NIH HHS; R01 HL077612/HL/NHLBI NIH HHS; R01 HL086719/HL/NHLBI NIH HHS; R01-HL077612/HL/NHLBI NIH HHS; R01-HL086719/HL/NHLBI NIH HHS; T32 HL007287/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/von Willebrand Factor
Comments/Corrections

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