Document Detail


Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces.
MedLine Citation:
PMID:  20616226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to epidemiologic studies, a negative correlation exists between exercise amount and subsequent cancer development risk in the large intestine. The proportion of secondary bile acids (SBA) in the large intestine is related to subsequent risk for colorectal carcinogenesis. The aim of this study was to investigate the effects of voluntary wheel running exercise and dietary intervention on bile acid (BA) metabolism in the large intestine. Wistar/ST rats (6 wk old) were divided into two groups, exercise and sedentary, after acclimation. Four days after the animals were assigned to a group, rats in each group were fed diets supplemented with different carbohydrate sources including dextrin, sucrose, and lactose. The wheel running period was 4 wk in the exercise group, whereas rats in the sedentary group remained in individual cages during this period. BA composition in collected feces was analyzed with ultraperformance liquid chromatography-electrospray ionization mass spectrometry. We found that wheel running exercise decreased plasma concentrations of cholesterol, triglyceride, and free fatty acids. These decreases were accompanied by a reduction in the proportion of SBA to primary BA (PBA) in feces; however, daily excretion of BA was comparable regardless of wheel running exercise. In addition, ingestion of lactose decreased the SBA-to-PBA ratio and suppressed production of hyodeoxycholic acid in feces. In conclusion, voluntary wheel running exercise, in combination with dietary intervention, could independently reduce the SBA-to-PBA ratio within the large intestine without changing BA excretion. These changes may contribute to the prevention of colorectal carcinogenesis.
Authors:
Masahito Hagio; Megumi Matsumoto; Takaji Yajima; Hiroshi Hara; Satoshi Ishizuka
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Publication Detail:
Type:  Journal Article     Date:  2010-07-08
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2011-01-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-8     Citation Subset:  IM    
Affiliation:
Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / metabolism*
Cholesterol / blood
Chromatography, Liquid
Colorectal Neoplasms / metabolism,  prevention & control
Dietary Carbohydrates / administration & dosage*
Fatty Acids, Nonesterified / blood
Feces / chemistry*
Intestine, Large / metabolism*
Lactose / administration & dosage*
Male
Physical Exertion*
Rats
Rats, Wistar
Spectrometry, Mass, Electrospray Ionization
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Carbohydrates; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 57-88-5/Cholesterol; 63-42-3/Lactose

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