| Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces. | |
| | |
MedLine Citation:
|
PMID: 20616226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
According to epidemiologic studies, a negative correlation exists between exercise amount and subsequent cancer development risk in the large intestine. The proportion of secondary bile acids (SBA) in the large intestine is related to subsequent risk for colorectal carcinogenesis. The aim of this study was to investigate the effects of voluntary wheel running exercise and dietary intervention on bile acid (BA) metabolism in the large intestine. Wistar/ST rats (6 wk old) were divided into two groups, exercise and sedentary, after acclimation. Four days after the animals were assigned to a group, rats in each group were fed diets supplemented with different carbohydrate sources including dextrin, sucrose, and lactose. The wheel running period was 4 wk in the exercise group, whereas rats in the sedentary group remained in individual cages during this period. BA composition in collected feces was analyzed with ultraperformance liquid chromatography-electrospray ionization mass spectrometry. We found that wheel running exercise decreased plasma concentrations of cholesterol, triglyceride, and free fatty acids. These decreases were accompanied by a reduction in the proportion of SBA to primary BA (PBA) in feces; however, daily excretion of BA was comparable regardless of wheel running exercise. In addition, ingestion of lactose decreased the SBA-to-PBA ratio and suppressed production of hyodeoxycholic acid in feces. In conclusion, voluntary wheel running exercise, in combination with dietary intervention, could independently reduce the SBA-to-PBA ratio within the large intestine without changing BA excretion. These changes may contribute to the prevention of colorectal carcinogenesis. |
| | |
Authors:
|
Masahito Hagio; Megumi Matsumoto; Takaji Yajima; Hiroshi Hara; Satoshi Ishizuka |
Related Documents
:
|
2947746 - Effects of exercise on the capillary vasculature of the rat heart. 9000156 - Effects of acute physical exercise on central serotonergic systems. 2095716 - Interactive effects of physostigmine and exercise on cholinesterase activity in red blo... 2607446 - Effect of sympathetic nerves on composition and distensibility of cerebral arterioles i... 1924076 - Pharmacological stress echocardiography in the evaluation of coronary artery disease. 4393346 - Comparison of the effect of alprenolol and propranolol on specific airway conductance i... |
Publication Detail:
|
Type: Journal Article Date: 2010-07-08 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 109 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-10 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 663-8 Citation Subset: IM |
Affiliation:
|
Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile Acids and Salts / metabolism* Cholesterol / blood Chromatography, Liquid Colorectal Neoplasms / metabolism, prevention & control Dietary Carbohydrates / administration & dosage* Fatty Acids, Nonesterified / blood Feces / chemistry* Intestine, Large / metabolism* Lactose / administration & dosage* Male Physical Exertion* Rats Rats, Wistar Spectrometry, Mass, Electrospray Ionization Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Dietary Carbohydrates; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 57-88-5/Cholesterol; 63-42-3/Lactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LEC fate regulators: the 3 musketeers.
Next Document: Reduction in tendon elasticity from unloading is unrelated to its hypertrophy.