| Voluntary wheel running is beneficial to the amino acid profile of lysine-deficient rats. | |
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MedLine Citation:
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PMID: 20233939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats voluntarily run up to a dozen kilometers per night when their cages are equipped with a running wheel. Daily voluntary running is generally thought to enhance protein turnover. Thus, we sought to determine whether running worsens or improves protein degradation caused by a lysine-deficient diet and whether it changes the utilization of free amino acids released by proteolysis. Rats were fed a lysine-deficient diet and were given free access to a running wheel or remained sedentary (control) for 4 wk. Amino acid levels in plasma, muscle, and liver were measured together with plasma insulin levels and tissue weight. The lysine-deficient diet induced anorexia, skeletal muscle loss, and serine and threonine aminoacidemia, and it depleted plasma insulin and essential amino acids in skeletal muscle. Allowing rats to run voluntarily improved these symptoms; thus, voluntary wheel running made the rats less susceptible to dietary lysine deficiency. Amelioration of the declines in muscular leucine and plasma insulin observed in running rats could contribute to protein synthesis together with the enhanced availability of lysine and other essential amino acids in skeletal muscle. These results indicate that voluntary wheel running under lysine-deficient conditions does not enhance protein catabolism; on the contrary, it accelerates protein synthesis and contributes to the maintenance of muscle mass. The intense nocturnal voluntary running that characterizes rodents might be an adaptation of lysine-deficient grain eaters that allows them to maximize opportunities for food acquisition. |
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Authors:
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Kenji Nagao; Makoto Bannai; Shinobu Seki; Nobuhiro Kawai; Masato Mori; Michio Takahashi |
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Publication Detail:
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Type: Journal Article Date: 2010-03-16 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 298 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E1170-8 Citation Subset: IM |
Affiliation:
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Institute of Life Sciences, Ajinomoto Co. Inc., Kawasaki-ku, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Argininosuccinate Lyase / genetics, metabolism Insulin / blood Liver / enzymology, metabolism Lysine / deficiency*, metabolism Male Motor Activity / physiology* Muscle Proteins / biosynthesis, metabolism Muscle, Skeletal / metabolism* Phosphoglycerate Dehydrogenase / genetics, metabolism RNA / chemistry, genetics Random Allocation Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Muscle Proteins; 11061-68-0/Insulin; 56-87-1/Lysine; 57-13-6/Urea; 63231-63-0/RNA; EC 1.1.1.95/Phosphoglycerate Dehydrogenase; EC 4.3.2.1/Argininosuccinate Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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