Document Detail


Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice.
MedLine Citation:
PMID:  22988135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The circadian system co-ordinates the temporal patterning of behaviour and many underlying biological processes. In some cases, the regulated outputs of the circadian system, such as activity, may be able to feed back to alter core clock processes. In our studies, we used four wheel-access conditions (no access; free access; early night; and late night) to manipulate the duration and timing of activity while under the influence of a light-dark cycle. In wild-type mice, scheduled wheel access was able to increase ambulatory activity, inducing a level of exercise driven at various phases of the light-dark cycle. Scheduled exercise also manipulated the magnitude and phasing of the circadian-regulated outputs of heart rate and body temperature. At a molecular level, the phasing and amplitude of PER2::LUCIFERASE (PER2::LUC) expression rhythms in the SCN and peripheral tissues of Per2::Luc knockin mice were altered by scheduled exercise. We then tested whether scheduled wheel access could improve deficits observed in vasointestinal polypeptide-deficient mice under the influence of a light-dark cycle. We found that scheduled wheel access during the late night improved many of the behavioural, physiological and molecular deficits previously described in vasointestinal polypeptide-deficient mice. Our results raise the possibility that scheduled exercise could be used as a tool to modulate daily rhythms and, when applied, may counteract some of the negative impacts of ageing and disease on the circadian system.
Authors:
Analyne M Schroeder; Danny Truong; Dawn H Loh; Maria C Jordan; Kenneth P Roos; Christopher S Colwell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-17
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6213-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology
Body Temperature / physiology
Circadian Rhythm / physiology*
Gene Expression
Heart Rate / physiology
Mice
Mice, Transgenic
Period Circadian Proteins / genetics
Physical Conditioning, Animal / physiology*
Vasoactive Intestinal Peptide / physiology*
Grant Support
ID/Acronym/Agency:
5T32NS7101-33/NS/NINDS NIH HHS; F31NS070529/NS/NINDS NIH HHS; T32 GM065823/GM/NIGMS NIH HHS; T32 HD007228/HD/NICHD NIH HHS; T32 NS058280/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Per2 protein, mouse; 0/Period Circadian Proteins; 37221-79-7/Vasoactive Intestinal Peptide
Comments/Corrections
Comment In:
J Physiol. 2012 Dec 1;590(Pt 23):5929   [PMID:  23204099 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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