Document Detail


Voluntary running-wheel exercise decreases the threshold for rewarding intracranial self-stimulation.
MedLine Citation:
PMID:  22845707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical exercise has mood-enhancing and antidepressant properties although the mechanisms underlying these effects are not known. The present experiment investigated the effects of prolonged access to a running wheel on electrical self-stimulation of the lateral hypothalamus (LHSS), a measure of hedonic state, in rats. Rats with continuous voluntary access to a running wheel for either 2 or 5 weeks exhibited dramatic leftward shifts in the effective current 50 (ECu50; current value that supports half of maximum responding) of their LHSS current-response functions compared to their baselines, indicating a decrease in reward threshold, whereas control rats current-response functions after 2 or 5 weeks were not significantly different from baseline. An inverse correlation existed between the change in ECu50 from baseline and the amount an animal had run in the day prior to LHSS testing, indicating that animals that exhibited higher levels of running showed a more robust decrease in LHSS threshold. We conclude that long-term voluntary exercise increases sensitivity to rewarding stimuli, which may contribute to its antidepressant properties.
Authors:
Michael J Morris; Elisa S Na; Alan Kim Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  126     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-31     Completed Date:  2012-12-20     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  582-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal
Body Weight
Conditioning, Operant / physiology*
Electric Stimulation / methods
Hypothalamic Area, Lateral / physiology*
Male
Physical Conditioning, Animal*
Random Allocation
Rats
Rats, Sprague-Dawley
Reward*
Running / physiology*
Self Stimulation
Grant Support
ID/Acronym/Agency:
DK 66086/DK/NIDDK NIH HHS; HL 098207/HL/NHLBI NIH HHS; HL 14388/HL/NHLBI NIH HHS; MH 80241/MH/NIMH NIH HHS; R01 MH080241/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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