Document Detail

Voluntary physical exercise alters attentional orienting and social behavior in a rat model of attention-deficit/hyperactivity disorder.
MedLine Citation:
PMID:  19485566     Owner:  NLM     Status:  MEDLINE    
The effects of voluntary physical exercise on attentional function and social behavior were examined in male and female spontaneously hypertensive rats (SHR), a commonly used animal model of attention-deficit/hyperactivity disorder (ADHD). Rats in the exercise groups had free access to a running wheel for 2 weeks and then all rats received nonreinforced presentations of a visual stimulus (light) during the 1st training session, followed by daily sessions in which the light was paired with food. Nonexercising male and female SHR rats exhibited more unconditioned orienting behavior than Wistar-Kyoto rats. SHRs also exhibited impaired conditioning when the light was paired with food. Exercise reduced orienting in female SHRs but not in male SHRs. In the social interaction task, nonexercising male and female SHRs interacted more with an unfamiliar rat than Wistar-Kyoto rats. Exercise reduced the number of social interactions in female SHRs but not male SHRs. There were no differences in general locomotor activity observed between the nonexercising and exercising SHRs. These data indicate that exercise may preferentially benefit female SHRs, and has implications for using exercise as an intervention for ADHD and for understanding sex differences in the effects of exercise on behavior.
Michael E Hopkins; Mita Sharma; Gretchen C Evans; David J Bucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  123     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  599-606     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 APA, all rights reserved.
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.
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MeSH Terms
Analysis of Variance
Association Learning*
Attention Deficit Disorder with Hyperactivity / psychology*
Conditioning (Psychology)
Disease Models, Animal
Motor Activity
Photic Stimulation
Physical Conditioning, Animal*
Rats, Inbred SHR
Rats, Inbred WKY
Sex Characteristics
Social Behavior*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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