Document Detail

Voluntary exercise and tail shock have differential effects on amphetamine-induced dopaminergic toxicity in adult BALB/c mice.
MedLine Citation:
PMID:  16940768     Owner:  NLM     Status:  MEDLINE    
Exercise exerts neuroprotective effects and facilitates neural recovery in animal models of Parkinson's disease. In the present studies, effects of exercise on amphetamine-induced dopaminergic toxicity were assessed in mice housed individually either with or without access to run wheels. Mice in run wheel cages ran approximately 20 000 revolutions/day (over 10 km/day). Some mice received amphetamine (18.5 mg/kg x 4 injections) whereas controls received saline. Amphetamine caused a 90% dopamine depletion in mice housed either with or without run wheels. A precipitous drop was seen in run wheel activity following amphetamine, lasting at least 7 days. A significant decrease in food intake, water intake and body weight also occurred. The opportunity to exercise did not facilitate behavioral or neurochemical recovery at 1, 2 or 3 days, or 2 weeks after injections. Therefore, shock stress, a component of some forced exercise studies, was evaluated to determine whether stress without exercise provided neuroprotection against amphetamine. Results indicate that shock stress exerted neuroprotective effects, reducing the amphetamine-induced dopamine depletion. It is concluded that voluntary running does not afford either behavioral or neuroprotection nor facilitate recovery from amphetamine-induced dopaminergic toxicity; rather, elevated glucocorticoid levels following shock stress were associated with a reduction in the dopamine depletion.
Kirsten M Carlson; George C Wagner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  17     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2007-01-29     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-84     Citation Subset:  IM    
Department of Psychology, Busch Campus, Rutgers University, New Brunswick, New Jersey 08854, USA.
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MeSH Terms
Amphetamine / toxicity*
Cell Survival / drug effects,  physiology
Corpus Striatum / drug effects,  physiopathology
Corticosterone / blood
Dopamine / metabolism*
Drinking / drug effects,  physiology
Eating / drug effects,  physiology
Injections, Subcutaneous
Mice, Inbred BALB C
Neurons / drug effects,  physiology
Neurotoxins / toxicity*
Parkinsonian Disorders / physiopathology*
Physical Exertion / physiology*
Stress, Physiological / physiopathology*
Grant Support
Reg. No./Substance:
0/Neurotoxins; 300-62-9/Amphetamine; 50-22-6/Corticosterone

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