| Voluntary exercise and tail shock have differential effects on amphetamine-induced dopaminergic toxicity in adult BALB/c mice. | |
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MedLine Citation:
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PMID: 16940768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise exerts neuroprotective effects and facilitates neural recovery in animal models of Parkinson's disease. In the present studies, effects of exercise on amphetamine-induced dopaminergic toxicity were assessed in mice housed individually either with or without access to run wheels. Mice in run wheel cages ran approximately 20 000 revolutions/day (over 10 km/day). Some mice received amphetamine (18.5 mg/kg x 4 injections) whereas controls received saline. Amphetamine caused a 90% dopamine depletion in mice housed either with or without run wheels. A precipitous drop was seen in run wheel activity following amphetamine, lasting at least 7 days. A significant decrease in food intake, water intake and body weight also occurred. The opportunity to exercise did not facilitate behavioral or neurochemical recovery at 1, 2 or 3 days, or 2 weeks after injections. Therefore, shock stress, a component of some forced exercise studies, was evaluated to determine whether stress without exercise provided neuroprotection against amphetamine. Results indicate that shock stress exerted neuroprotective effects, reducing the amphetamine-induced dopamine depletion. It is concluded that voluntary running does not afford either behavioral or neuroprotection nor facilitate recovery from amphetamine-induced dopaminergic toxicity; rather, elevated glucocorticoid levels following shock stress were associated with a reduction in the dopamine depletion. |
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Authors:
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Kirsten M Carlson; George C Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioural pharmacology Volume: 17 ISSN: 0955-8810 ISO Abbreviation: Behav Pharmacol Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2007-01-29 Revised Date: 2009-07-07 |
Medline Journal Info:
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Nlm Unique ID: 9013016 Medline TA: Behav Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 475-84 Citation Subset: IM |
Affiliation:
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Department of Psychology, Busch Campus, Rutgers University, New Brunswick, New Jersey 08854, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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toxicity* Animals Cell Survival / drug effects, physiology Corpus Striatum / drug effects, physiopathology Corticosterone / blood Dopamine / metabolism* Drinking / drug effects, physiology Eating / drug effects, physiology Electroshock* Injections, Subcutaneous Male Mice Mice, Inbred BALB C Neurons / drug effects, physiology Neurotoxins / toxicity* Parkinsonian Disorders / physiopathology* Physical Exertion / physiology* Stress, Physiological / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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NS43981/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurotoxins; 300-62-9/Amphetamine; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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