| Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. | |
| | |
MedLine Citation:
|
PMID: 18971258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exercise is a mechanism for maintenance of body weight in humans. Morbidly obese human patients have been shown to possess single nucleotide polymorphisms in the melanocortin-4 receptor (MC4R). MC4R knockout mice have been well characterized as a genetic model that possesses phenotypic metabolic disorders, including obesity, hyperphagia, hyperinsulinemia, and hyperleptinemia, similar to those observed in humans possessing dysfunctional hMC4Rs. Using this model, we examined the effect of voluntary exercise of MC4R knockout mice that were allowed access to a running wheel for a duration of 8 wk. Physiological parameters that were measured included body weight, body composition of fat and lean mass, food consumption, body length, and blood levels of cholesterol and nonfasted glucose, insulin, and leptin. At the termination of the experiment, hypothalamic mRNA expression levels of neuropeptide Y (NPY), agouti-related protein (AGRP), proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), orexin, brain-derived neurotropic factor (BDNF), phosphatase with tensin homology (Pten), melanocortin-3 receptor (MC3R), and NPY-Y1R were determined. In addition, islet cell distribution and function in the pancreas were examined. In the exercising MC4R knockout mice, the pancreatic islet cell morphology and other physiological parameters resembled those observed in the wild-type littermate controls. Gene expression profiles identified exercise as having a significant effect on hypothalamic POMC, orexin, and MC3R levels. Genotype had a significant effect on AGRP, POMC, CART, and NPY-Y1R, with an exercise and genotype interaction effect on NPY gene expression. These data support the hypothesis that voluntary exercise can prevent the genetic predisposition of melanocortin-4 receptor-associated obesity and diabetes. |
| | |
Authors:
|
Carrie Haskell-Luevano; Jay W Schaub; Amy Andreasen; Kim R Haskell; Marcus C Moore; Lorraine M Koerper; Francois Rouzaud; Henry V Baker; William J Millard; Glenn Walter; S A Litherland; Zhimin Xiang |
Related Documents
:
|
23181968 - Effects of unilateral knee extensor muscle fatigue induced by stimulated and voluntary ... 16940768 - Voluntary exercise and tail shock have differential effects on amphetamine-induced dopa... 10942908 - Interactive and delayed effects of pyridostigmine and physical stress on biochemical an... 18295408 - Low intensity exercise attenuates disease progression and stimulates cell proliferation... 21921818 - Analysis of heart rate deflection points to predict the anaerobic threshold by a comput... 2047408 - Neuromuscular aspects in development of exercise countermeasures. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-10-29 |
Journal Detail:
|
Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 23 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-30 Completed Date: 2009-02-16 Revised Date: 2012-02-15 |
Medline Journal Info:
|
Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
|
Languages: eng Pagination: 642-55 Citation Subset: IM |
Affiliation:
|
Department of Pharmacodynamics, University of Florida, PO Box 100487, Gainesville, FL 32610, USA. carrie@cop.ufl.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Glucose / metabolism Body Weight Cholesterol / blood Diabetes Mellitus, Type 2 / genetics, metabolism*, prevention & control* Gene Expression Regulation Insulin / blood Leptin / blood Liver / anatomy & histology, metabolism Magnetic Resonance Imaging Mice Mice, Knockout Obesity / genetics, metabolism*, prevention & control* Organ Size Pancreas / anatomy & histology, metabolism Phenotype Physical Conditioning, Animal / physiology* RNA, Messenger / genetics Receptor, Melanocortin, Type 4 / deficiency*, genetics, metabolism Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
|
R01DK057080/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Insulin; 0/Leptin; 0/RNA, Messenger; 0/Receptor, Melanocortin, Type 4; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association w...
Next Document: Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of ...