| Voluntary exercise and its effects on body composition depend on genetic selection history. | |
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MedLine Citation:
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PMID: 19282822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known about how genetic variation affects the capacity for exercise to change body composition. We examined the extent to which voluntary exercise alters body composition in several lines of selectively bred mice compared to controls. Lines studied included high runner (HR) (selected for high wheel running), M16 (selected for rapid weight gain), Institute of Cancer Research (ICR) (randomly bred as control for M16), M16i (an inbred line derived from M16), HE (selected for high percentage of body fat while holding body weight constant), LF (selected for low percentage of body fat), C57BL/6J (common inbred line), and the F1 between HR and C57BL/6J. Body weight and body fat were recorded before and after 6 days of free access to running wheels in males and females that were individually caged. Total food intake was measured during this 6-day period. All pre- and postexercise measures showed significant strain effects. While HR mice predictably exercised at higher levels, all other selection lines had decreased levels of wheel running relative to ICR. The HR x B6 F1 ran at similar levels to HR demonstrating complete dominance for voluntary exercise. Also, all strains lost body fat after exercise, but the relationships between exercise and changes in percent body were not uniform across genotypes. These results indicate that there is significant genetic variation for voluntary exercise and its effects on body composition. It is important to carefully consider genetic background and/or selection history when using mice to model effects of exercise on body composition, and perhaps, other complex traits as well. |
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Authors:
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Derrick L Nehrenberg; Kunjie Hua; Daria Estrada-Smith; Theodore Garland; Daniel Pomp |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-03-12 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 17 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-25 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1402-9 Citation Subset: IM |
Affiliation:
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Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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physiology Animals Body Composition / genetics*, physiology* Body Weight / genetics, physiology Eating / genetics, physiology Female Male Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Inbred Strains Models, Animal Physical Conditioning, Animal / physiology* Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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1 P20 RR020649/RR/NCRR NIH HHS; DK076050/DK/NIDDK NIH HHS; DK56350/DK/NIDDK NIH HHS; GM00678/GM/NIGMS NIH HHS; T32 ES007126/ES/NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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