Document Detail

Voluntary exercise induces structural remodeling in the hearts of dystrophin-deficient mice.
MedLine Citation:
PMID:  21104863     Owner:  NLM     Status:  MEDLINE    
In this exploratory study, we test the hypothesis that voluntary exercise affects the progression of dystrophic changes in the left ventricle of the heart. Wild-type (C57BL/10ScSn) and dystrophin-deficient (mdx) mice, aged 7 weeks, were divided into sedentary and exercise-treated groups and tested for differences in cardiac histomorphometry. Exercised mdx mice were found to exhibit significantly enlarged ventricles and thinner lateral ventricular walls than sedentary mdx mice (P < 0.05). Trichrome staining indicated the presence of fibrotic lesions in the left ventricular myocardium in 20% of the exercised mdx group. Fibrotic lesions were not found in control or sedentary mdx mice. No histomorphometric differences were found between treatment groups in wild-type mice. Our findings suggest voluntary exercise may accelerate the progression of ventricular dilation and fibrosis in young mdx mice. The effects of exercise on cardiac remodeling should be considered during the treatment of cardiac disease in dystrophin-deficient patients.
Jeffrey M Costas; David J Nye; Jessica B Henley; Jeffrey H Plochocki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  42     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  881-5     Citation Subset:  IM    
Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona 85308, USA.
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MeSH Terms
Fibrosis / pathology
Heart / physiopathology
Mice, Inbred mdx
Motor Activity / physiology
Muscular Dystrophy, Animal / pathology*,  physiopathology,  therapy*
Myocardium / pathology*
Physical Conditioning, Animal*
Statistics, Nonparametric

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