| Voluntary exercise induces structural remodeling in the hearts of dystrophin-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 21104863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this exploratory study, we test the hypothesis that voluntary exercise affects the progression of dystrophic changes in the left ventricle of the heart. Wild-type (C57BL/10ScSn) and dystrophin-deficient (mdx) mice, aged 7 weeks, were divided into sedentary and exercise-treated groups and tested for differences in cardiac histomorphometry. Exercised mdx mice were found to exhibit significantly enlarged ventricles and thinner lateral ventricular walls than sedentary mdx mice (P < 0.05). Trichrome staining indicated the presence of fibrotic lesions in the left ventricular myocardium in 20% of the exercised mdx group. Fibrotic lesions were not found in control or sedentary mdx mice. No histomorphometric differences were found between treatment groups in wild-type mice. Our findings suggest voluntary exercise may accelerate the progression of ventricular dilation and fibrosis in young mdx mice. The effects of exercise on cardiac remodeling should be considered during the treatment of cardiac disease in dystrophin-deficient patients. |
| | |
Authors:
|
Jeffrey M Costas; David J Nye; Jessica B Henley; Jeffrey H Plochocki |
Related Documents
:
|
12714353 - Inhibition of hibernation by exercise is not affected by intergeniculate leaflets lesio... 16699173 - Inhibitory effects of voluntary running wheel exercise on uvb-induced skin carcinogenes... 2882873 - Comparative studies of calcium-channel blockers and beta-blockers in essential hyperten... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Muscle & nerve Volume: 42 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
|
Languages: eng Pagination: 881-5 Citation Subset: IM |
Affiliation:
|
Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona 85308, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Fibrosis / pathology Heart / physiopathology Mice Mice, Inbred mdx Motor Activity / physiology Muscular Dystrophy, Animal / pathology*, physiopathology, therapy* Myocardium / pathology* Physical Conditioning, Animal* Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Progressive resistance voluntary wheel running in the mdx mouse.
Next Document: Nemaline myopathy type 6: clinical and myopathological features.