| Voluntary exercise increases oligodendrogenesis in spinal cord. | |
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MedLine Citation:
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PMID: 20374076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise has been shown to increase hippocampal neurogenesis, but the effects of exercise on oligodendrocyte generation have not yet been reported. In this study, we evaluated the hypothesis that voluntary exercise may affect neurogenesis, and more in particular, oligodendrogenesis in the thoracic segment of the intact spinal cord of adult nestin-GFP transgenic mice. Voluntary exercise for 7 and 14 days increased nestin-GFP expression around the ependymal area. In addition, voluntary exercise for 7 days significantly increased nestin-GFP expression in both the white and gray matter of the thoracic segment of the intact spinal cord, whereas, 14-day exercise decreased nestin-GFP expression. Markers for immature oligodendrocytes (transferrin and CNPase) were significantly increased after 7 days of voluntary exercise. These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury. |
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Authors:
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W Krityakiarana; A Espinosa-Jeffrey; C A Ghiani; P M Zhao; N Topaldjikian; F Gomez-Pinilla; M Yamaguchi; N Kotchabhakdi; J de Vellis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-07-08 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 280-90 Citation Subset: IM |
Affiliation:
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Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Count / methods Gene Expression Regulation / physiology Green Fluorescent Proteins / genetics Intermediate Filament Proteins / genetics Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins / genetics, physiology Neurogenesis / physiology* Oligodendroglia / physiology* Physical Conditioning, Animal / methods* Spinal Cord / cytology*, physiology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD004612/HD/NICHD NIH HHS; HD006576/HD/NICHD NIH HHS; R01 NS056413-01A2/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/nestin; 147336-22-9/Green Fluorescent Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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