Document Detail

Voluntary exercise in pregnant rats improves post-lactation maternal bone parameters but does not affect offspring outcomes in early life.
MedLine Citation:
PMID:  23196262     Owner:  NLM     Status:  In-Data-Review    
Objectives: The objectives of this study were to examine the effects of voluntary exercise during pregnancy on maternal post-lactation bone parameters and offspring growth. Methods: Pregnant Wistar rats were housed in conventional cages (control), or were housed in raised cages requiring them to rise to an erect, bipedal stance to obtain food/water, throughout pregnancy. Dual energy X-ray absorptiometry and peripheral quantitative computed tomography scans were performed pre-mating and post-weaning. Maternal stress was assessed by fecal corticosterone measurement. Offspring weights were assessed at postnatal days 1 and 25 (weaning). Results: Changes in bone mineral over the pregnancy/lactation period were site-specific. Exercise did not affect loss of bone mineral from the lumbar spine, but did attenuate the loss of trabecular bone mineral from the tibial metaphysis and enhance the strength strain index and cross-sectional moment of inertia at the tibial diaphysis (P≤0.05) in dams in the exercised group. Fecal corticosterone did not differ between dam groups. There were no significant differences in offspring weight between the exercised and control group at either time point. Conclusions: Voluntary exercise in the pregnant rat can improve some post-lactation bone parameters and does not adversely affect early postnatal outcomes of the offspring.
B V Rosa; H T Blair; M H Vickers; P C Morel; J F Cockrem; E C Firth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of musculoskeletal & neuronal interactions     Volume:  12     ISSN:  1108-7161     ISO Abbreviation:  J Musculoskelet Neuronal Interact     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101084496     Medline TA:  J Musculoskelet Neuronal Interact     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  IM    
National Research Centre for Growth and Development, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
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