| Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice. | |
| | |
MedLine Citation:
|
PMID: 14724049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cannabinoid CB1 receptor (CB1R) inverse agonists reduce appetite and body weight (BW) gain in various species. Exercise is thought to be a natural reward process and the cannabinoid system is also believed to influence reward. We tested the hypothesis that voluntary exercise would augment the effects of AM251, a CB1R inverse agonist, on food intake (FI) and BW loss in murine genetic models of obesity. ob/ob, agouti yellow (A(y)), and lean C57BL/6J mice were treated via oral gavage with vehicle or AM251 (1, 3, or 10 mg/kg) 1 h before the dark cycle. The suppressive effects of 3 and 10 mg/kg AM251 on overnight FI, BW gain, and water intake (WI) were significant in ob/ob mice. In contrast, in A(y) mice, 10 mg/kg AM251 decreased FI and BW gain while it did not influence WI. Food consumption of ob/ob and A(y) mice, as evidenced by feeding frequency (FF) and feeding duration (FD), was reduced by AM251 for 4-6 h. AM251 at these doses had no impact on the appetitive behavior or BW gain of lean mice. After a 1-week wash-out period, mice were given running wheels in their home cages. With running wheel exercise, lean and obese mice exhibited increased sensitivity to AM251. Low voluntary wheel running activity of ob/ob mice precluded detection of combined effects of AM251 and exercise in this genetic model of obesity. Lean and agouti mice given AM251 combined with exercise lost a greater amount of BW than with AM251 alone. Our data suggest that voluntary exercise can enhance CB1R inverse agonist effects on appetite and BW loss in both lean and agouti obese mice. |
| | |
Authors:
|
Dan Zhou; Lauren P Shearman |
Related Documents
:
|
23059859 - Acute exercise influences reward processing in highly trained and untrained men. 22323549 - Tissue doppler echocardiography improves the diagnosis of coronary artery stenosis in s... 9451619 - Effects of voluntary activity and genetic selection on aerobic capacity in house mice (... 23493359 - Capz and actin capping dynamics increase in myocytes after a bout of exercise and abate... 19144689 - Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progres... 12783429 - Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. 3739909 - Low-frequency requirements for recording ischemic st-segment abnormalities in coronary ... 12776849 - Relations between perceptual and physiological response during incremental exercise fol... 15247199 - Inhibitory effects of hyperthermia on mechanisms involved in autoresuscitation from hyp... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 77 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-15 Completed Date: 2004-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 117-25 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Merck Research Laboratories, RY80Y-150, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects, physiology Dose-Response Relationship, Drug Eating / drug effects, physiology Female Mice Mice, Inbred C57BL Mice, Obese Physical Conditioning, Animal / physiology* Piperidines / pharmacology, therapeutic use Pyrazoles / pharmacology, therapeutic use Receptor, Cannabinoid, CB1 / agonists*, antagonists & inhibitors, physiology* Thinness / physiopathology* Weight Loss / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/AM 251; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of nitric oxide on morphine self-administration in rat.
Next Document: Early developmental lead exposure increases sensitivity to cocaine in a self-administration paradigm...