| Voluntary breathing influences corticospinal excitability of nonrespiratory finger muscles. | |
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MedLine Citation:
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PMID: 21160006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study aimed to investigate neurophysiologic mechanisms mediating the newly discovered phenomenon of respiratory-motor interactions and to explore its potential clinical application for motor recovery. First, young and healthy subjects were instructed to breathe normally (NORM); to exhale (OUT) or inhale (IN) as fast as possible in a self-paced manner; or to voluntarily hold breath (HOLD). In experiment 1 (n = 14), transcranial magnetic stimulation (TMS) was applied during 10% maximal voluntary contraction (MVC) finger flexion force production or at rest. The motor-evoked potentials (MEPs) were recorded from flexor digitorum superficialis (FDS), extensor digitorum communis (EDC), and abductor digiti minimi (ADM) muscles. Similarly, in experiment 2 (n = 11), electrical stimulation (ES) was applied to FDS or EDC during the described four breathing conditions while subjects maintained 10%MVC of finger flexion or extension and at rest. In the exploratory clinical experiments (experiment 3), four patients with chronic neurological disorders (three strokes, one traumatic brain injury) received a 30-min session of breathing-controlled ES to the impaired EDC. In experiment 1, the EDC MEP magnitudes increased significantly during IN and OUT at both 10%MVC and rest; the FDS MEPs were enhanced only at 10%MVC, whereas the ADM MEP increased only during OUT, compared with NORM for both at rest and 10%MVC. No difference was found between NORM and HOLD for all three muscles. In experiment 2, when FDS was stimulated, force response was enhanced during both IN and OUT, but only at 10%MVC. When EDC was stimulated, force response increased at both 10%MVC and rest, only during IN, but not OUT. The averaged response latency was 83 ms for the finger extensors and 79 ms for the finger flexors. After a 30-min intervention of ES to EDC triggered by forced inspiration in experiment 3, we observed a significant reduction in finger flexor spasticity. The spasticity reduction lasted for ≥ 4 wk in all four patients. TMS and ES data, collectively, support the phenomenon that there is an overall respiration-related enhancement on the motor system, with a strong inspiration-finger extension coupling during voluntary breathing. As such, breathing-controlled electrical stimulation (i.e., stimulation to finger extensors delivered during the voluntary inspiratory phase) could be applied for enhancing finger extension strength and finger flexor spasticity reduction in poststroke patients. |
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Authors:
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Sheng Li; William Zev Rymer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-12-15 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 105 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-06-16 Revised Date: 2012-05-04 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 512-21 Citation Subset: IM |
Affiliation:
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University of Texas Health Science Center at Houston, Department of Physical Medicine and Rehabilitation, Houston, TX 77030, USA. sheng.li@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Evoked Potentials, Motor / physiology* Excitatory Postsynaptic Potentials / physiology Female Fingers / innervation, physiology* Humans Male Muscle Contraction / physiology* Muscle, Skeletal / innervation, physiology* Pyramidal Tracts / physiology* Respiratory Mechanics / physiology* Respiratory Muscles / innervation, physiology Volition / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS060774/NS/NINDS NIH HHS; R01 NS060774-03/NS/NINDS NIH HHS; R01 NS060774-04/NS/NINDS NIH HHS; R01-NS-060774/NS/NINDS NIH HHS |
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