Document Detail

Voluntary movement controlled by the surface EMG signal for tissue-engineered skeletal muscle on a gripping tool.
MedLine Citation:
PMID:  23444880     Owner:  NLM     Status:  MEDLINE    
We have developed a living prosthesis consisting of a living muscle-powered device, which is controlled by neuronal signals to recover some of the functions of a lost extremity. A tissue-engineered skeletal muscle was fabricated with two anchorage points from a primary rat myoblast cultured in a collagen Matrigel mixed gel. Differentiation to the skeletal muscle was confirmed in the tissue-engineered skeletal muscle, and the contraction force increased with increasing frequency of electric stimulation. Then, the tissue-engineered skeletal muscle was assembled into a gripper-type microhand. The tissue-engineered skeletal muscle of the microhand was stimulated electrically, which was then followed by the voluntary movement of the subject's hand. The signal of the surface electromyogram from a subject was processed to mimic the firing spikes of a neuromuscular junction to control the contraction of the tissue-engineered skeletal muscle. The tele-operation of the microhand was demonstrated by optical microscope observations.
Ken-ichiro Kabumoto; Takayuki Hoshino; Yoshitake Akiyama; Keisuke Morishima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-06-11
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  19     ISSN:  1937-335X     ISO Abbreviation:  Tissue Eng Part A     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-01     Completed Date:  2014-02-10     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1695-703     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Electromyography / methods*
Muscle, Skeletal / metabolism,  physiology*
Myoblasts / cytology,  metabolism
Rats, Wistar
Tissue Engineering / methods*

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