Document Detail

Volumetric q-space imaging by 3D diffusion-weighted MRI.
MedLine Citation:
PMID:  18068929     Owner:  NLM     Status:  MEDLINE    
High b-value diffusion magnetic resonance imaging (MRI) enables us to detect far smaller architectures, by using q-space analysis, than the resolution in conventional MRI. Average displacement, one of the q-space parameters, quantitatively reflects architecture size and is very useful in observing small changes in microstructures in vivo (e.g., neurodegeneration, tumor heterogeneity, and others). Diffusion-weighted imaging (DWI) is performed by a two-dimensional (2D) multislice method; however, due to finite slice thickness and slice gap, there is a partial-volume effect that makes it difficult to detect the net q-space signal. On the other hand, three-dimensional (3D) MRI, having the advantages of very thin slice thickness and no slice gap (contiguous slices), allows volumetric evaluation acquired in a small isotropic voxel, as compared to 2D multislice imaging. Little is known about the isotropic high-resolution 3D DWI application to q-space analysis. In this study, we have developed and implemented a high b-value 3D DWI sequence, applied q-space analysis to study the reliability of high b-value 3D DWI and obtained a microscopic analytical map with isotropic high resolution and less contamination.
Keigo Hikishima; Kazuo Yagi; Tomokazu Numano; Kazuhiro Homma; Naotaka Nitta; Tetsu Nakatani; Koji Hyodo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-20
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  26     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-45     Citation Subset:  IM    
Biomedical Sensing and Imaging Group, National Institute of Advanced Industrial, Science and Technology (AIST), AIST Tsukuba East, Tsukuba 305-8564, Ibaraki, Japan.
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MeSH Terms
Diffusion Magnetic Resonance Imaging / instrumentation*,  methods*
Equipment Design
Image Enhancement / methods
Image Processing, Computer-Assisted / methods
Imaging, Three-Dimensional
Models, Statistical
Phantoms, Imaging

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