| Volumetric modulated arc radiotherapy for esophageal cancer. | |
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MedLine Citation:
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PMID: 21940159 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V(20Gy) and V(30Gy) dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D(35%) of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V(10Gy) and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans. |
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Authors:
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Nagarajan Vivekanandan; Padmanaban Sriram; S A Syam Kumar; Narayanan Bhuvaneswari; Kamalakannan Saranya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-20 |
Journal Detail:
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Title: Medical dosimetry : official journal of the American Association of Medical Dosimetrists Volume: - ISSN: 1873-4022 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908862 Medline TA: Med Dosim Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medical Physics, Cancer Institute, Chennai, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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