Document Detail


Volumetric quantitative computed tomography measurement precision for volumes and densities of tarsal and metatarsal bones.
MedLine Citation:
PMID:  21723764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetic foot diseases, such as ulcerations, infections, and neuropathic (Charcot's) arthropathy, are major complications of diabetes mellitus (DM) and peripheral neuropathy (PN) and may cause osteolysis (bone loss) in foot bones. The purposes of our study were to make computed tomography (CT) measurements of foot-bone volumes and densities and to determine measurement precision (percent coefficients of variation for root-mean-square standard deviations) and least significant changes (LSCs) in these percentages that could be considered biologically real with 95% confidence. Volumetric quantitative CT scans were performed and repeated on 10 young healthy subjects and 13 subjects with DM and PN. Two raters used the original- and repeat-scan data sets to make measurements of volumes and bone mineral densities (BMDs) of the tarsal and metatarsal bones of the 2 feet (24 bones). Precisions for the bones ranged from 0.1% to 0.9% for volume measurements and from 0.6% to 1.9% for BMD measurements. The LSCs ranged from 0.4% to 2.5% for volume measurements and from 1.5% to 5.4% for BMD measurements. Volumetric quantitative CT provides precise measurements of volume and BMD for metatarsal and tarsal bones, where diabetic foot diseases commonly occur.
Authors:
Paul K Commean; Jared A Kennedy; Karen A Bahow; Charles F Hildebolt; Lu Liu; Kirk E Smith; Mary K Hastings; Tao Ju; Fred W Prior; David R Sinacore
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Publication Detail:
Type:  Journal Article     Date:  2011-07-01
Journal Detail:
Title:  Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry     Volume:  14     ISSN:  1094-6950     ISO Abbreviation:  J Clin Densitom     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-08-03     Completed Date:  2011-10-18     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9808212     Medline TA:  J Clin Densitom     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Density*
Cone-Beam Computed Tomography*
Diabetic Foot / radiography*
Female
Humans
Male
Metatarsal Bones / radiography*
Tarsal Bones / radiography*
Grant Support
ID/Acronym/Agency:
P30 AR057235/AR/NIAMS NIH HHS; R21 DK079457/DK/NIDDK NIH HHS; R21 DK079457-03/DK/NIDDK NIH HHS; TL1 TR000449/TR/NCATS NIH HHS
Comments/Corrections

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