Document Detail


Volumetric MRI and MRS and early motor development of infants born preterm.
MedLine Citation:
PMID:  22207464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the relationship between volumetric magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in infants born less than 30 weeks gestation and early motor development at 6 months adjusted age.
METHODS: Twenty infants born preterm and 4 born at term (control) underwent MRI with volumetric analysis and MRS prior to neonatal intensive care unit discharge. Infants were assessed using the Bayley Scale of Infant Development at 6 months adjusted age.
RESULTS: At 6 months, infants born preterm with low motor scores had a reduction in their subcortical gray matter. No differences were detected in other brain structures. N-acetylaspartate/choline correlated with white matter (R = 0.45, P = .03), gray matter (R = 0.43, P = .04), and cerebellar volume (R = 0.6, P = .002) but not with 6-month motor performance.
CONCLUSION: There is an association between diminished subcortical gray matter volume and low motor scores. Our data suggest that volumetric MRI performed prior to hospital discharge may have some role in counseling parents about potential motor delays.
Authors:
Erlita Gadin; Michele Lobo; David A Paul; Kanik Sem; Karl V Steiner; Amy Mackley; Kert Anzilotti; Cole Galloway
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association     Volume:  24     ISSN:  1538-005X     ISO Abbreviation:  Pediatr Phys Ther     Publication Date:  2012  
Date Detail:
Created Date:  2011-12-30     Completed Date:  2012-05-03     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8912748     Medline TA:  Pediatr Phys Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00679471
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Brain / growth & development*
Case-Control Studies
Central Nervous System / growth & development
Disability Evaluation
Female
Health Status Indicators
Humans
Infant, Newborn
Infant, Premature*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Male
Motor Skills*
Prospective Studies
Severity of Illness Index
Statistics as Topic
Grant Support
ID/Acronym/Agency:
R01 HD051748/HD/NICHD NIH HHS; R01 HD051748-02/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
Pediatr Phys Ther. 2012 Spring;24(1):44-5   [PMID:  22207465 ]

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