| Volumetric Imaging of Blood Flow within Cochlea in Gerbil in vivo. | |
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MedLine Citation:
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PMID: 20495618 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Meniere's disease. Advances have been made in the areas of vital microscopic studies of micro-circulation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo three-dimensional (3-D) mapping of microvascular perfusion within the cochlea. To overcome this limitation we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques. |
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Authors:
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Niloy Choudhury; Fangyi Chen; Xiaorui Shi; Alfred L Nuttall; Ruikang K Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society Volume: PP ISSN: 1558-4542 ISO Abbreviation: - Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101212349 Medline TA: IEEE J Sel Top Quantum Electron Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Affiliation:
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Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR 97239. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL093140-01S1//NHLBI NIH HHS; R01 HL093140-02//NHLBI NIH HHS; R03 DC008888-02//NIDCD NIH HHS; R01 DC000105-34//NIDCD NIH HHS; R01 DC010201-01//NIDCD NIH HHS; R01 HL093140-01//NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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