Document Detail

Volumetric and functional assessment of ventricles in pulmonary hypertension on 3-dimensional echocardiography.
MedLine Citation:
PMID:  23018765     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Non-invasive assessment of volume and function on the right ventricle (RV) for pulmonary hypertension (PH) is limited.
METHODS AND RESULTS: Patients with PH (n=23) underwent 3-dimensional (D) echocardiography (3DECHO), with cardiac magnetic resonance imaging to confirm its precision, and right heart catheterization. On linear regression analysis the RV end-systolic volume index (ESVI) was positively correlated with pulmonary vascular resistance (PVR) and mean pulmonary arterial pressure (mPAP; R=0.42 and 0.46, P=0.03 and 0.03, respectively). The RV end-diastolic volume index (EDVI) was positively correlated with mPAP (R=0.41, P<0.05). The left ventricular (LV) EDVI was inversely correlated with PVR (R=-0.48, P=0.02). The RV ejection fraction was inversely correlated with PVR and mean right atrial pressure (mRAP; R=-0.57, and -0.45, P=0.004, and 0.03, respectively). RVEDVI/LVEDVI and RVESVI/LVESVI (the diastolic and systolic remodeling indices, respectively) had a significantly positive linear relationship with PVR (R=0.67 and 0.55, P=0.0005 and 0.006, respectively), and the former had a significantly positive linear relationship with mRAP (R=0.42, P<0.05). During the recovery process in 1 specific case, the remodeling indices maintained a significant linear relationship with the hemodynamic parameters.
CONCLUSIONS: Novel indices provided by 3DECHO may be utilized as alternative indicators of hemodynamic changes in PH patients.
Toshiro Inaba; Atsushi Yao; Tomoko Nakao; Masaru Hatano; Hisataka Maki; Teruhiko Imamura; Taro Shiga; Tadashi Yamazaki; Makoto Sonoda; Koichiro Kinugawa; Takahiro Shiota; Junichi Suzuki; Katsu Takenaka; Yasunobu Hirata; Ryozo Nagai
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  198-206     Citation Subset:  IM    
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Echocardiography, Three-Dimensional*
Heart Ventricles / physiopathology,  ultrasonography
Hypertension, Pulmonary / physiopathology,  ultrasonography
Middle Aged
Stroke Volume*
Vascular Resistance*
Ventricular Function, Right*
Ventricular Remodeling*

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