| Volumetric analysis of coronary plaque characterization in patients with metabolic syndrome using 64-slice multi-detector computed tomography. | |
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MedLine Citation:
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PMID: 20679734 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Metabolic syndrome (MetS) is associated with adverse cardiovascular events and mortality, where acute coronary syndrome significantly impacts on mortality and morbidity. In contrast, evidences have accumulated that the lipid-rich plaque might play a critical role in acute coronary syndrome. METHODS AND RESULTS: The study population consisted of 94 patients with suspected angina pectoris who underwent multi-detector computed tomography (MDCT). Of those, we identified 41 with MetS. In MDCT analysis, low-density plaque volume (LDPV) (42 ± 28 vs 24 ± 18 mm(3), P=0.0003), moderate-density plaque volume (105 ± 41 vs 82 ± 33 mm(3), P=0.003), total plaque volume (164 ± 70 vs 118 ± 59 mm(3), P=0.0008) and %LDPV (24.2 ± 10.0 vs 18.3 ± 7.1%, P=0.01) were significantly increased in the MetS group compared to the non-MetS group. Multivariate linear regression analysis after adjusting for confounding variables revealed that MetS was significantly correlated with an increase in %LDPV (β=0.48, P=0.0001). Multivariate logistic regression analysis for lipid-rich plaque after adjusting for confounding variables indicated that MetS was significantly associated with lipid-rich plaque (odds ratio: 5.99, 95% confidence intervals: 1.94-18.6, P=0.002). CONCLUSIONS: Patients with MetS were strongly related to having a lipid-rich composition in their coronary plaque, as detected by MDCT. |
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Authors:
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Kosuke Arai; Hideki Ishii; Tetsuya Amano; Tadayuki Uetani; Michio Nanki; Nobuyuki Marui; Masataka Kato; Kiminobu Yokoi; Hirohiko Ando; Soichiro Kumagai; Ken Harada; Daiji Yoshikawa; Satoru Ohshima; Tatsuaki Matsubara; Toyoaki Murohara |
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Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 2146-51 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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