Document Detail


Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients.
MedLine Citation:
PMID:  1627044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vivo brain imaging and postmortem investigations have demonstrated structural anomalies in the brains of schizophrenic patients. However, previous studies have not established clear relationships between the characteristic symptoms of the disorder and neuropathologic changes in specific brain regions. We have obtained high-resolution magnetic resonance brain images of first-episode schizophrenic and normal control subjects and, with a computerized mensuration system, determined the volumes of the different components of the entire ventricular system. Volumes of ventricular segments were significantly larger in patients than controls (differences ranged from 17% to 40%). Temporal horn enlargement consistently demonstrated significant correlations with a broad range of schizophrenic symptoms. Our data indicate that anomalies of limbic structures in the medial temporal lobe surrounding the temporal horn play a crucial pathophysiologic role in schizophrenia.
Authors:
G Degreef; M Ashtari; B Bogerts; R M Bilder; D N Jody; J M Alvir; J A Lieberman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  49     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-12     Completed Date:  1992-08-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-7     Citation Subset:  AIM; IM    
Affiliation:
Hillside Hospital, Glen Oaks, NY 11004.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cerebral Ventricles / anatomy & histology*
Female
Functional Laterality
Humans
Limbic System / anatomy & histology,  physiopathology
Magnetic Resonance Imaging* / instrumentation,  statistics & numerical data
Male
Minicomputers
Psychiatric Status Rating Scales
Reproducibility of Results
Schizophrenia / diagnosis*,  physiopathology
Schizophrenic Psychology
Temporal Lobe / anatomy & histology,  physiopathology
Grant Support
ID/Acronym/Agency:
MH00537/MH/NIMH NIH HHS; MH41646/MH/NIMH NIH HHS; MH41960/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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