| Volumes of the hippocampus and amygdala in patients with borderline personality disorder: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 19663654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Individuals with borderline personality disorder (BPD) often exhibit impulsive and aggressive behavior. The hippocampus and amygdala form part of the limbic system, which plays a central role in controlling such expressions of emotional reactivity. There are mixed results in the literature regarding whether patients with BPD have smaller hippocampal and amygdalar volume relative to healthy controls. To clarify the precise nature of these mixed results, we performed a meta-analysis to aggregate data on the size of the hippocampus and amygdala in patients with BPD. Seven publications involving six studies and a total of 104 patients with BPD and 122 healthy controls were included. A significantly smaller volume was found in both the right and left hippocampi and amygdala of patients with BPD compared to healthy controls. These findings raise the possibility that reduced hippocampal and amygdalar volumes are biological substrates of some symptoms of BPD. |
| | |
Authors:
|
Paulo Menezes Nunes; Amy Wenzel; Karinne Tavares Borges; Cristianne Ribeiro Porto; Renato Maiato Caminha; Irismar Reis de Oliveira |
Related Documents
:
|
12084424 - The relationship between positive symptoms and instrumental work functioning in schizop... 19395244 - Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: a voxe... 17712404 - Csf metabolic and proteomic profiles in patients prodromal for psychosis. 18514324 - Empathic abilities in people with schizophrenia. 9681714 - Has the prognosis for patients with pauci-immune necrotizing glomerulonephritis improved? 19902224 - Influence of colectomy on hydrogen excretion in breath. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Review |
Journal Detail:
|
Title: Journal of personality disorders Volume: 23 ISSN: 1943-2763 ISO Abbreviation: J. Pers. Disord. Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-11 Completed Date: 2009-12-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710838 Medline TA: J Pers Disord Country: United States |
Other Details:
|
Languages: eng Pagination: 333-45 Citation Subset: IM |
Affiliation:
|
Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
pathology* Borderline Personality Disorder / pathology*, psychology Case-Control Studies Hippocampus / pathology* Humans Magnetic Resonance Imaging |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduced platelet monoamine oxidase type B activity and lymphocyte muscarinic receptor binding in unm...
Next Document: The 10-year course of social security disability income reported by patients with borderline persona...