Document Detail


Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease.
MedLine Citation:
PMID:  25303108     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.
Authors:
Veronica van der Land; Channa T Hijmans; Marieke de Ruiter; Henri J M M Mutsaerts; Marjon H Cnossen; Marc Engelen; Charles B L M Majoie; Aart J Nederveen; Martha A Grootenhuis; Karin Fijnvandraat
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-10
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-10     Completed Date:  -     Revised Date:  2014-10-11    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
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