Document Detail

Volume reflex in diabetes.
MedLine Citation:
PMID:  9217876     Owner:  NLM     Status:  MEDLINE    
After examining various components of the volume reflex in different models of diabetic rats, it is clear that the neural component of the volume reflex is altered in the early stage of diabetes. Nevertheless, the mechanisms involved in the neural component need to be examined further in diabetes. In terms of the humoral component of the effector limb of the volume reflex, the actions of ANF within the kidney appear to contribute to the altered volume reflex in diabetes. Results of our preliminary studies suggest that intrarenal factors may also contribute to the blunted renal excretory responses to acute VE in early diabetes. Finally, the present review has outlined the major abnormalities in the volume reflex in diabetes and the gaps in our knowledge of the various components of the volume reflex in diabetes.
K P Patel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  34     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-08-11     Completed Date:  1997-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  81-90     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198-4575, USA.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Diabetes Mellitus / physiopathology*
Kidney / physiopathology
Water-Electrolyte Balance*
Grant Support

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