Document Detail


Volume reduction in prefrontal gray matter in unsuccessful criminal psychopaths.
MedLine Citation:
PMID:  15866549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although studies of neurologic patients have suggested that prefrontal structural impairments may predispose to sociopathy, it is unknown whether there is a relationship between psychopathy and prefrontal volume in individuals from the community and whether any prefrontal structural impairment is specific to "unsuccessful" (caught) psychopaths as opposed to "successful" (uncaught) psychopaths. This study tests the hypothesis that psychopathy is associated with a reduction in prefrontal gray volume but that this abnormality is specific to unsuccessful psychopaths. METHOD: Prefrontal gray and white matter volumes were assessed using structural magnetic resonance imaging (MRI) in 16 unsuccessful psychopaths, 13 successful psychopaths, and 23 control subjects. RESULTS: Higher total as well as subfactor psychopathy scores (arrogant/deceptive, affective, and impulsive/unstable) were all associated with low prefrontal gray volume. Unsuccessful psychopaths, but not successful psychopaths, had a 22.3% reduction in prefrontal gray matter volume compared with control subjects. CONCLUSIONS: These results demonstrating for the first time a prefrontal structural deficit in community psychopaths provide partial support for a prefrontal theory of psychopathy but highlight an important difference between successful and unsuccessful psychopaths.
Authors:
Yaling Yang; Adrian Raine; Todd Lencz; Susan Bihrle; Lori LaCasse; Patrick Colletti
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  57     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-06-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1103-8     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Southern California, Los Angeles, California 90089-1061, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antisocial Personality Disorder / pathology*,  psychology*
Cognition / physiology
Crime*
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Personality / physiology
Prefrontal Cortex / pathology*
Psychiatric Status Rating Scales
Grant Support
ID/Acronym/Agency:
5 R03 MH50940-02/MH/NIMH NIH HHS; K02 MH01114-01/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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