Document Detail

Volume overload heart failure: length-tension curves, and response to beta-agonists, Ca2+, and glucagon.
MedLine Citation:
PMID:  32775     Owner:  NLM     Status:  MEDLINE    
Left ventricular force-generating capacity was determined in 19 anesthetized dogs with heart failure (HF) from aortocaval fistula. At the time of study all dogs had ascites, edema, and elevated pulmonary wedge pressure. Length-contractile force (CF) curves recorded from the left ventricle (LV) with a modified Walton-Brodie arch indicated that the LV was operating on the ascending limb of the length-CF curve at 62.4 +/- 0.1% Lmax in the normal group and in the HF group at 83.4 +/- 2.7% Lmax. In HF the length-CF curve was depressed when compared to normal and was further depressed when CF in grams was normalized for changes in LV wall thickness and expressed as g/cm2. Additionally, dose-response curves of CF in response to injected norepinephrine, isoproterenol, glucagon, and calcium were depressed when compared to the normal group while the response of heart rate and blood pressure was not different. These findings indicate that volume overload HF is associated with depressed ventricular muscle function and a depressed response to inotropic drugs.
W H Newman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  235     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H690-700     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Blood Pressure
Calcium / pharmacology*
Dose-Response Relationship, Drug
Glucagon / pharmacology*
Heart Failure / physiopathology*
Heart Rate / drug effects
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects
Norepinephrine / pharmacology*
Stimulation, Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 51-41-2/Norepinephrine; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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