| Volume overload heart failure: length-tension curves, and response to beta-agonists, Ca2+, and glucagon. | |
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MedLine Citation:
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PMID: 32775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular force-generating capacity was determined in 19 anesthetized dogs with heart failure (HF) from aortocaval fistula. At the time of study all dogs had ascites, edema, and elevated pulmonary wedge pressure. Length-contractile force (CF) curves recorded from the left ventricle (LV) with a modified Walton-Brodie arch indicated that the LV was operating on the ascending limb of the length-CF curve at 62.4 +/- 0.1% Lmax in the normal group and in the HF group at 83.4 +/- 2.7% Lmax. In HF the length-CF curve was depressed when compared to normal and was further depressed when CF in grams was normalized for changes in LV wall thickness and expressed as g/cm2. Additionally, dose-response curves of CF in response to injected norepinephrine, isoproterenol, glucagon, and calcium were depressed when compared to the normal group while the response of heart rate and blood pressure was not different. These findings indicate that volume overload HF is associated with depressed ventricular muscle function and a depressed response to inotropic drugs. |
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Authors:
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W H Newman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 235 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H690-700 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology Animals Blood Pressure Calcium / pharmacology* Dogs Dose-Response Relationship, Drug Glucagon / pharmacology* Heart Failure / physiopathology* Heart Rate / drug effects Isoproterenol / pharmacology* Myocardial Contraction / drug effects Norepinephrine / pharmacology* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 51-41-2/Norepinephrine; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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