Document Detail


Volume independent stimulation of renin secretion by a single dose of amiloride in man.
MedLine Citation:
PMID:  12404882     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regulation of renin secretion is not understood in detail. There is evidence that amiloride (CAS 17440-83-4) has a stimulatory effect on the renin secretion but it is still in question whether this is volume and/or sodium independent. The purpose of this study was to investigate whether a single dose of amiloride has a direct stimulatory effect on the renin secretion in humans independent of its diuretic effect. Blood pressure, plasma renin activities and plasma aldosterone concentrations as well as serum electrolytes and serum creatinine were assessed in 11 healthy male humans over a period of 6 hours after a single dose of 20 mg of amiloride (Midamor), or placebo. Furthermore every hour urine was collected for analysis of urinary creatinine and electrolytes. To avoid a possible effect on the renin secretion via augmented diuresis induced by amiloride the urinary volume loss was replaced by 0.9% NaCl solution. There was a decrease in plasma renin activities and plasma aldosterone concentrations after amiloride and placebo administration, but the plasma renin activity after amiloride was significantly higher compared with placebo. Also the plasma aldosterone concentration was higher after amiloride compared with placebo, but the difference did not reach statistical significance. Serum and urinary concentrations of sodium and potassium clearly confirmed the known potassium-saving and natriuretic effect of amiloride. Serum creatinine concentrations decreased and urinary sodium chloride concentrations increased due to the administered volume load using physiologic sodium chloride solution. The present study provides evidence that amiloride induces renin secretion by direct mechanisms in man, which might go along with augmented aldosterone secretion.
Authors:
Dierk Endemann; Jörg Marienhagen; Mike Stubanus; Rainer J Luger; Michael Fischereder; Günter A J Riegger; Bernhard K Krämer
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  52     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-30     Completed Date:  2002-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
Affiliation:
Klinik und Poliklinik für Innere Medizin II, Klinikum der Universität Regensburg, Germany. Dierk.Endemann@klinik.uni-regensburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood
Amiloride / pharmacology*
Blood Pressure / drug effects
Chlorides / blood,  urine
Creatinine / blood
Cross-Over Studies
Diuretics / pharmacology*
Humans
Kidney / drug effects,  metabolism
Male
Potassium / blood,  urine
Renin / metabolism*
Saline Solution, Hypertonic
Single-Blind Method
Sodium / blood,  urine
Urea / blood
Urodynamics / drug effects
Chemical
Reg. No./Substance:
0/Chlorides; 0/Diuretics; 0/Saline Solution, Hypertonic; 2609-46-3/Amiloride; 52-39-1/Aldosterone; 57-13-6/Urea; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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