Document Detail

Volume change of uterine myomas during pregnancy: do myomas really grow?
MedLine Citation:
PMID:  16962519     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To estimate changes in uterine myoma volume during pregnancy. DESIGN: Review of departmental electronic perinatal database and medical records. Canadian Task Force Classification II-3. SETTING: Obstetrical ultrasound unit in an academic tertiary care center. PATIENTS: One hundred-seven patients diagnosed with uterine myomas during pregnancy and who had two or more obstetrical ultrasounds in different periods of pregnancy. INTERVENTIONS: We analyzed the change in volume of uterine myomas between the first half of pregnancy (up until 19 weeks), third quarter (20-30 weeks), and last quarter (31 weeks to term). The volume of largest uterine myoma was calculated using the formula Volume (mm3)=Pi/6x(length mm)x(width mm)x(height mm). MEASUREMENTS AND MAIN RESULTS: The mean age of the population was 31+/-6 years. Between the first and the second study periods, the percentage of uterine myomas that decreased in size was 55.1% (95% CI: 43-66), with a mean decrease in volume of 35%+/-4%; while the percentage of uterine myomas that enlarged was 44.9% (95% CI: 34-56), with a mean increase in volume of 69%+/-11%. Between the second and the third study periods, 75% (95% CI: 56-87) became smaller, with a mean decrease in volume of 30%+/-3%; while 25% (95% CI: 13-43) enlarged, with a mean increase in volume of 102%+/-62%. CONCLUSION: Contrary to common belief, we found that uterine myomas commonly decrease in volume over the course of pregnancy.
Ahmad O Hammoud; Radwan Asaad; Jay Berman; Marjorie C Treadwell; Sean Blackwell; Michael P Diamond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of minimally invasive gynecology     Volume:  13     ISSN:  1553-4650     ISO Abbreviation:  -     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-11     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235322     Medline TA:  J Minim Invasive Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  386-90     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA.
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MeSH Terms
Leiomyoma / pathology*,  ultrasonography
Longitudinal Studies
Pregnancy Complications, Neoplastic / pathology*,  ultrasonography
ROC Curve
Retrospective Studies
Tumor Burden*
Ultrasonography, Prenatal
Uterine Neoplasms / pathology*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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