Document Detail


Volume change of double-crosslinked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks.
MedLine Citation:
PMID:  22975627     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the present paper we report the development of redox responsive biocompatible polymer gels for the first time. Double crosslinked poly(aspartic acid) hydrogels were prepared by using two different cross-linking agents simultaneously. One of the cross-linker was diaminobutane (DAB), the other was cystamine (CYS). The relative amount of DAB and CYS molecules was varied in wide range, meanwhile the total amount of cross-linker molecules (DAB+CYS) was kept constant. DAB provides stable cross-links, whereas CYS cross-linker contains disulfide bonds, which can be broken by reduction. The cleavage of disulfide crosslinks results in enhanced swelling and significant decrease in the elastic modulus of the gels. These novel type of stimuli responsive gels are promising candidates for new swelling controlled release matrix.
Authors:
T Gyenes; D Juriga; Ji-Heung Kim; M Zrinyi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-10
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physical Chemistry and Materials Science, Budapest University of Technology, and Economics, H-1521 Budapest, Hungary.
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