| Volume changes of corpus striatum, thalamus, hippocampus and lateral ventricles in posttraumatic stress disorder (PTSD) patients suffering from headaches and without therapy. | |
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MedLine Citation:
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PMID: 20857373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: In the present study, we have hypothesized that volume changes of the caudate nucleus, putamen, globus pallidus, hippocampus, thalamus, and lateral ventricle in newly-diagnosed, male PTSD patients without therapy are more pronounced in those with headaches. To confirm or reject our hypothesis, we have undertaken an extensive study of forty-nine PTSD patients. PATIENTS AND METHODS: To confirm or reject our hypothesis, we have undertaken an extensive study of forty-nine PTSD male patients that underwent MRI scanning immediately upon admittance for the treatment. Based on headache frequency, they were classified into three groups: group 1 included patients with headaches at least twice a week; group 2 consisted of patients with headaches less than twice a week; and group 3 consisted of patients without headaches. All MRI scans underwent software-based volume compute and statistical processing. RESULTS: 39 out of 49 patients with PTSD suffered from headaches. Bilaterally, volume decreases were noted in groups 1 and 2 compared to group 3 for the caudate nucleus, putamen, hippocampus and lateral ventricle. Differences in globus pallidus and thalamus among groups appeared to be insignificant. CONCLUSION: The present study revealed a bilateral volume decrease of the caudate nucleus, putamen and hippocampus in PTSD male subjects without therapy. Intensity of volume alterations correlated with Hamilton's depression rating score; regression analysis uncovered correlated changes in the caudate nucleus, putamen and hippocampus, and an inverse correlation with the volume of the lateral ventricle in the PTSD patients. |
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Authors:
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B R Filipovic; B Djurovic; S Marinkovic; L Stijak; M Aksic; V Nikolic; A Starcevic; V Radonjic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
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Title: Central European neurosurgery Volume: 72 ISSN: 1868-4912 ISO Abbreviation: Cent Eur Neurosurg Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-10 Completed Date: 2011-12-06 Revised Date: 2012-03-23 |
Medline Journal Info:
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Nlm Unique ID: 101501500 Medline TA: Cent Eur Neurosurg Country: Germany |
Other Details:
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Languages: eng Pagination: 133-7 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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School of Medicne in Belgrade, Institute of Anatomy Belgrade, Serbia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Corpus Striatum / pathology* Depression / psychology Globus Pallidus / pathology Headache / etiology, pathology* Hippocampus / pathology* Humans International Classification of Diseases Lateral Ventricles / pathology* Magnetic Resonance Imaging Male Middle Aged Pain Measurement Psychiatric Status Rating Scales Putamen / pathology Stress Disorders, Post-Traumatic / complications, pathology*, therapy Thalamus / pathology* |
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