| Voltammetry as a virtual potentiometric sensor in modelling of a metal-ligand system and refinement of stability constants. Part 4. An electrochemical study of NiII complexes with methylene diphosphonic acid. | |
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MedLine Citation:
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PMID: 16213588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Ni(II)-MDP-OH system (MDP=methylene diphosphonic acid) and stability constants of complexes formed at ionic strength 0.15M at 298K were established by direct current polarography (DCP) and glass electrode potentiometry (GEP). The final M-L-OH model could only be arrived to by employing recent concept of virtual potentiometry (VP). VP-data were generated from non-equilibrium and dynamic DC polarographic technique. The VP and GEP data were refined simultaneously by software dedicated to potentiometric studies of metal complexes. Species distribution diagrams that were generated for different experimental conditions employed in this work assisted in making the final choice regarding the metal-ligand model. The model established contains ML, ML(2), ML(OH) and ML(OH)(2) with stability constants, as logbeta, 7.94+/-0.02, 13.75+/-0.02, 12.04 (fixed value), and 16.75+/-0.05, respectively. It has been demonstrated that virtual potential must be used in modelling operations (predictions of species formed) when a polarographic signal decreases significantly due to the formation of polarographically inactive species (or formation of inert complexes). The linear free energy relationships that included stability constant logK(1) for Ni(II)-MDP established in this work together with other available data were used to predict logK(1) values for Sm(III) and Ho(III) with MDP. The logK(1) values for Sm(III)-MDP and Ho(III)-MDP were estimated to be 9.65+/-0.10 and 9.85+/-0.10, respectively. |
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Authors:
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Ignacy Cukrowski; Daniel M Mogano; Jan Rijn Zeevaart |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-06 |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 99 ISSN: 0162-0134 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-29 Completed Date: 2006-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 2308-21 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Pretoria, NW-1 Building, Pretoria 0002, South Africa. ignacy.cukrowski@up.ac.za |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone and Bones
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drug effects,
metabolism Diphosphonates / chemistry*, pharmacology Electrochemistry Humans Ligands Models, Chemical Nickel / chemistry*, pharmacology Polarography Potentiometry Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates; 0/Ligands; 1984-15-2/methylene diphosphonate; 7440-02-0/Nickel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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