| Voltammetric studies on the antibiotic drug cefoperazone quantification and pharmacokinetic studies. | |
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MedLine Citation:
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PMID: 16782297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fully validated simple, sensitive and selective square-wave stripping voltammetry procedure was described for the trace quantification of cefoperazone in bulk form, formulations and human serum/plasma. The procedure was based on reduction of the adsorbed drug onto a hanging mercury drop electrode. The procedural conditions were optimized as: frequency=60Hz, scan increment=8mV, pulse amplitude=25mV, preconcentration potential=-0.3V (versus Ag/Ag/KCl(s)), preconcentration duration=60-150s and an acetate buffer of pH 4.2 as a supporting electrolyte. A limit of detection of 4.5x10(-10)M and a limit of quantitation of 1.5x10(-9)M bulk cefoperazone were achieved following preconcentration of the drug onto the hanging mercury drop electrode for 150s. The proposed square-wave adsorptive cathodic stripping voltammetric procedure was successfully applied for trace quantification of cefoperazone in human serum and plasma. The achieved limits of detection and quantitation of the drug in human serum were 6x10(-10)M (0.375ngml(-1)) and 2x10(-9)M (1.250ngml(-1)), respectively. The pharmacokinetic parameters of cefoperazone in plasma of hospitalized volunteers were successfully estimated. |
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Authors:
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E Hammam; M A El-Attar; A M Beltagi |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2006-06-19 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 42 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 523-7 Citation Subset: IM |
Affiliation:
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Chemistry Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt. essamhammam2k@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
/
analysis,
blood,
chemistry,
pharmacokinetics* Cefoperazone / analysis, blood, chemistry, pharmacokinetics* Electrochemistry / methods* Electrodes Humans Male Mercury Reference Values Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 62893-19-0/Cefoperazone; 7439-97-6/Mercury |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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