| Voltametric assessment of brain nitric oxide during heatstroke in rats. | |
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MedLine Citation:
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PMID: 9291142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anesthetized rats exposed to a high ambient temperature develop heatstroke with brain ischemia. Since nitric oxide (NO) plays an important role during normothermic ischemia, its cortical and cerebellar production were continuously assessed in pentobarbital anesthetized rats exposed to heat by using differential pulsed voltammetry. After 60 min at thermoneutrality, the rats were submitted to an ambient temperature of 40 degrees C until death. After 60 min in the heat, the rats were injected intraperitoneally with saline, MK801 (1 mg.kg(-1)), an antagonist of N-methyl-D-aspartate (NMDA) receptors, or L-arginine p-nitroanilide (L-ANA; 100 mg.kg(-1)), an inhibitor of NO synthase. Just before death, a 70% increase in NO production was observed in both the cerebellum and the cortex of saline-treated rats. The cortical increase in NO was not modified by MK801 while the NO signal was suppressed by L-ANA. |
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Authors:
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F Canini; L Bourdon; R Cespuglio; A Buguet |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 231 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: IM |
Affiliation:
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Département des facteurs humains, Centre de recherches du Service de santé des armées, La Tronche, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Brain Ischemia / complications, metabolism* Cerebellum / blood supply, metabolism, physiopathology Cerebral Cortex / blood supply, metabolism, physiopathology Electrophysiology Heat Stroke / complications, metabolism* Nitric Oxide / metabolism* Rats Rats, Sprague-Dawley Skin Temperature |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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