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Voltage dependence of intramembrane charge movement and conductance activation of batrachotoxin-modified sodium channels in frog node of Ranvier.
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MedLine Citation:
PMID:  6308127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium current and sodium channel intramembrane gating charge movement (Q) were monitored in voltage-clamped frog node of Ranvier after modification of all sodium channels by batrachotoxin (BTX). BTX caused an approximately threefold increase in steepness of the Q vs. voltage relationship and a 50-mV negative shift in its midpoint. The maximum amount of intramembrane charge was virtually identical before and after BTX treatment. BTX treatment eliminated the charge immobilization observed in untreated nodes after relatively long depolarizing pulses and slowed the rate of OFF charge movement after a pulse. After BTX treatment, the voltage dependence of charge movement was the same as the steady-state voltage dependence of sodium conductance activation. The observations are consistent with the hypothesis that BTX induces an aggregation of the charged gating particles associated with each channel and causes them to move as a unit having approximately three times the average valence of the individual particles. Movement of this single aggregated unit would open the BTX-modified sodium channel.
Authors:
J M Dubois; M F Schneider; B I Khodorov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general physiology     Volume:  81     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Batrachotoxins / pharmacology*
Electric Conductivity
Ion Channels / drug effects*,  physiology
Membranes / physiology
Rana esculenta
Ranvier's Nodes / metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Batrachotoxins; 0/Ion Channels
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 6 Year: 1983
Volume: 81 Issue: 6
First Page: 829 Last Page: 844
ID: 2215561
Publisher Id: 83267422
PubMed Id: 6308127

Voltage dependence of intramembrane charge movement and conductance activation of batrachotoxin-modified sodium channels in frog node of Ranvier


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