Document Detail

Voltage-addressable on/off microvalves for high-pressure microchip separations.
MedLine Citation:
PMID:  12498243     Owner:  NLM     Status:  MEDLINE    
We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and crosslinked polymer monoliths operate in water-acetonitrile mixtures and have been shown to hold off pressures as high as 350 bar (5000 p.s.i.). Open/closed flow ratios of 10(4) to 10(6) have been demonstrated over the pressure range 1.5-70 bar (20-1000 p.s.i.), and the pressure-leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips.
Brian J Kirby; Timothy J Shepodd; Ernest F Hasselbrink
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of chromatography. A     Volume:  979     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-05-14     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Microfluidics Department, Sandia National Laboratories, P.O. Box 969, MS 9951, Livermore, CA, USA.
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MeSH Terms
Chromatography, High Pressure Liquid / instrumentation*
Equipment Design

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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