Document Detail


Voltage-addressable on/off microvalves for high-pressure microchip separations.
MedLine Citation:
PMID:  12498243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and crosslinked polymer monoliths operate in water-acetonitrile mixtures and have been shown to hold off pressures as high as 350 bar (5000 p.s.i.). Open/closed flow ratios of 10(4) to 10(6) have been demonstrated over the pressure range 1.5-70 bar (20-1000 p.s.i.), and the pressure-leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips.
Authors:
Brian J Kirby; Timothy J Shepodd; Ernest F Hasselbrink
Related Documents :
10786493 - Increasing the safety of volumetric ultrafiltration control.
8165763 - Closure pressure studies of the tapered ileal segment and reinforced ileocecal valve in...
18042003 - Silodosin, a novel selective alpha 1a-adrenoceptor selective antagonist for the treatme...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of chromatography. A     Volume:  979     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-05-14     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Affiliation:
Microfluidics Department, Sandia National Laboratories, P.O. Box 969, MS 9951, Livermore, CA, USA. bjkirby@sandia.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / instrumentation*
Equipment Design
Semiconductors*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simultaneous separation of different enantiomeric pairs in capillary electrophoresis by mixing diffe...
Next Document:  Preparative-scale isoelectric trapping separations using a modified Gradiflow unit.