| Volatile fatty acid findings in vaginal fluid compared with symptoms, signs, other laboratory results, and susceptibility to tinidazole of malodorous vaginal discharges. | |
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MedLine Citation:
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PMID: 3522407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relevance of volatile fatty acids as a diagnostic test in 79 women with abnormal vaginal discharge was evaluated by a blind, randomised, and placebo controlled trial of tinidazole as a single oral 2 g dose. Automated gas chromatography of ether extracts of discharges taken before treatment showed volatile fatty acids in 18. Volatile fatty acids correlated with malodorous, colour, and microscopically assessed altered bacterial flora and clue cells. At follow up one week later, the odour, colour, and volatile fatty acids in the vaginal discharge of women treated with tinidazole had become normal more often than in those receiving placebo. The disappearance of volatile fatty acids correlated with clinically assessed improvement in women treated with tinidazole. The volatile fatty acid test as an indicator of anaerobic bacterial flora is objective, technically simple and fast, has few problems of sample size and transportation, and may be useful in the aetiological classification and follow up treatment of non-specific vaginal discharges. |
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Authors:
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A M Jokipii; L Jokipii; E Vesterinen; E Purola; E Vartiainen; J Paavonen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genitourinary medicine Volume: 62 ISSN: 0266-4348 ISO Abbreviation: Genitourin Med Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-07-30 Completed Date: 1986-07-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8503853 Medline TA: Genitourin Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 102-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Fluids
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analysis* Chromatography, Gas Clinical Trials as Topic Double-Blind Method Fatty Acids, Volatile / analysis* Female Humans Leukorrhea / drug therapy* Nitroimidazoles / therapeutic use* Random Allocation Tinidazole / therapeutic use* Vagina / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Volatile; 0/Nitroimidazoles; 19387-91-8/Tinidazole |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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