| Volatile anesthetics and mucociliary clearance. | |
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MedLine Citation:
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PMID: 18354365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this prospective, randomized, double blind study was to evaluate the possible modification of in vivo nasal mucociliary clearance by three different volatile agents: sevoflurane, isoflurane and desflurane, following intravenous induction and tracheal intubation. METHODS: Following institutional approval and informed consent, 60 patients scheduled for ear and neck surgery under general anaesthesia were randomized into three groups. Each group received sevoflurane (Group S), isoflurane (Group I) or desflurane (Group D) at 1 MAC concentrations after anaesthesia induction with propofol, remifentanil and tracheal intubation with cis-atracurium. Mucociliary clearance time was assessed by in vivo saccharin transit time (STT). We recorded the time elapsed until the first recognition of sweet taste, which was taken to represent transport of saccharin to the oropharynx. We noted the time in minutes at two time points, pre- and post-anaesthesia, under the same climatic conditions (room temperature 23 degrees C, relative humidity 60%). RESULTS: The mean STT values after sevoflurane, isoflurane and desflurane anaesthesia were 9.1+/-4.3, 6.7+/-2.8 and 7.1+/-3.1 min respectively (P>0.05). These were not significantly different among volatile anaesthetics in two measurements. CONCLUSION: Anaesthesia with volatile agents does not modify mucociliary clearance of nasal epithelium. |
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Authors:
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E Kesimci; S Bercin; A Kutluhan; A Ural; B Yamanturk; O Kanbak |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Minerva anestesiologica Volume: 74 ISSN: 1827-1596 ISO Abbreviation: Minerva Anestesiol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-20 Completed Date: 2008-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375272 Medline TA: Minerva Anestesiol Country: Italy |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Reanimation, Ataturk Training and Research Hospital, Ankara, Turkey. elvinku@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Inhalation / pharmacology* Double-Blind Method Female Humans Isoflurane / analogs & derivatives*, pharmacology* Male Methyl Ethers / pharmacology* Middle Aged Mucociliary Clearance / drug effects* Prospective Studies Volatilization |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane |
| Comments/Corrections | |
Comment In:
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Minerva Anestesiol. 2008 Apr;74(4):103-4
[PMID:
18354363
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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